ArticleThe Biochemical journal1995
The lysosomal membrane glycoproteins Lamp-1 and Lamp-2 are present in mobilizable organelles, but are absent from the azurophil granules of human neutrophils.
Article in The Biochemical journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 91 citations in OpenAlex.
- Neutrophil Activation Decreases Ability to Kill Oral Streptococcus gordonii.Molecular oral microbiology · 2026Article
- Article
- Neutrophil Heterogeneity Identifies an Association of LAMP1 With Proliferative Lupus Nephritis.European journal of immunology · 2025Article
- Neutrophil-like cells derived from the HL-60 cell-line as a genetically-tractable model for neutrophil degranulation.PloS one · 2024Article
- Article
- Bordetella parapertussis Circumvents Neutrophil Extracellular Bactericidal Mechanisms.PloS one · 2017Article
- Molecular mechanisms regulating secretory organelles and endosomes in neutrophils and their implications for inflammation.Immunological reviews · 2016Review
- Signal regulatory protein alpha is present in several neutrophil granule populations and is rapidly mobilized to the cell surface to negatively fine-tune neutrophil accumulation in inflammation.Journal of innate immunity · 2014Article
- Proteomic analysis of temporally stimulated ovarian cancer cells for biomarker discovery.Molecular & cellular proteomics : MCP · 2013Article
- MUNC13-4 protein regulates the oxidative response and is essential for phagosomal maturation and bacterial killing in neutrophils.The Journal of biological chemistry · 2012Article
- Rab27a and Rab27b regulate neutrophil azurophilic granule exocytosis and NADPH oxidase activity by independent mechanisms.Traffic (Copenhagen, Denmark) · 2010Article
- The role of neutrophils in the upper and lower respiratory tract during influenza virus infection of mice.Respiratory research · 2008Article
- Neuraminidase 1 is a negative regulator of lysosomal exocytosis.Developmental cell · 2008Article
- Neutrophil elastase, an acid-independent serine protease, facilitates reovirus uncoating and infection in U937 promonocyte cells.Virology journal · 2005Article
- The adaptor protein AP-4 as a component of the clathrin coat machinery: a morphological study.The Biochemical journal · 2005Article
- Transthyretin interacts with the lysosome-associated membrane protein (LAMP-1) in circulation.The Biochemical journal · 2004Article
- Lipopolysaccharide-induced granule mobilization and priming of the neutrophil response to Helicobacter pylori peptide Hp(2-20), which activates formyl peptide receptor-like 1.Infection and immunity · 2002Article
- Different glycosphingolipid composition in human neutrophil subcellular compartments.Glycoconjugate journal · 2001Article
- Wheat germ agglutinin induces NADPH-oxidase activity in human neutrophils by interaction with mobilizable receptors.Infection and immunity · 1999Article
- Targeting of a short peptide derived from the cytoplasmic tail of the G1 membrane glycoprotein of Uukuniemi virus (Bunyaviridae) to the Golgi complex.Journal of virology · 1998Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The subcellular localization of two members of a highly glycosylated protein group present in lysosomal membranes in most cells, the lysosome-associated membrane proteins 1 and 2 (Lamp-1 and Lamp-2), was examined in human neutrophil granulocytes. Antibodies that were raised against purified Lamp-1 adn Lamp-2 gave a distinct granular staining of the cytoplasm upon immunostaining of neutrophils. Subcellular fractionation was used to separate the azurophil and specific granules from a light-membrane fraction containing plasma membranes and secretory vesicles, and Western blotting was used to determine the presence of the Lamps in these fractions. The results show that Lamp-1 and Lamp-2 are present in the specific-granule-enriched fraction and in the light-membrane fraction, but not in the azurophil granules. Separation of secretory vesicles from plasma membranes disclosed that the light-membrane Lamps were present primarily in the secretory-vesicle-enriched fraction. During phagocytosis both Lamp-1 and Lamp-2 became markedly concentrated around the ingested particle and they both appear on the cell surface when the secretory organelles are mobilized.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.