ArticleThe Biochemical journal1995
Carrier-mediated fructose uptake significantly contributes to carbohydrate metabolism in human skeletal muscle.
Article in The Biochemical journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- Postexercise muscle glycogen synthesis with glucose, galactose, and combined galactose-glucose ingestion.American journal of physiology. Endocrinology and metabolism · 2023Trial
- Lactate, fructose and glucose oxidation profiles in sports drinks and the effect on exercise performance.PloS one · 2007Trial
- Article
- Randomized Trial: D-Glyceric Acid Activates Mitochondrial Metabolism in 50-60-Year-Old Healthy Humans.Frontiers in aging · 2021Article
- Review
- Beneficiary effect ofJournal of traditional and complementary medicine · 2018Article
- Sugar Metabolism in Hummingbirds and Nectar Bats.Nutrients · 2017Review
- Article
- Uric acid and transforming growth factor in fructose-induced production of reactive oxygen species in skeletal muscle.Nutrition reviews · 2016Review
- Fructose-Glucose Composite Carbohydrates and Endurance Performance: Critical Review and Future Perspectives.Sports medicine (Auckland, N.Z.) · 2015Review
- Sugar flux through the flight muscles of hovering vertebrate nectarivores: a review.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2014Review
- High sugar intake and development of skeletal muscle insulin resistance and inflammation in mice: a protective role for PPAR- δ agonism.Mediators of inflammation · 2013Article
- Glucose transporter expression in an avian nectarivore: the ruby-throated hummingbird (Archilochus colubris).PloS one · 2013Article
- Regulation of the fructose transporter GLUT5 in health and disease.American journal of physiology. Endocrinology and metabolism · 2008Review
- In vitro analysis of the glucose-transport system in GLUT4-null skeletal muscle.The Biochemical journal · 1999Article
- Biochemical and functional characterization of the GLUT5 fructose transporter in rat skeletal muscle.The Biochemical journal · 1998Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
To determine whether fructose can be utilized as a metabolic substrate for skeletal muscle in man, we investigated its incorporation into glycogen, its oxidation and lactate production in isolated human skeletal muscle. Rates of fructose oxidation and incorporation into glycogen increased in the presence of increasing fructose concentrations (0.1-1.0 mM). Lactate production increased 3-fold when extracellular fructose was increased from 0.1 to 0.5 mM. Cytochalasin B, a competitive inhibitor of hexose transport mediated by the GLUT1 and GLUT4 facilitative glucose transporters, completely inhibited insulin-stimulated glucose incorporation into glycogen and glucose oxidation (P < 0.01), but did not alter fructose incorporation into glycogen or fructose oxidation. Insulin (1000 mu-units/ml) increased glucose incorporation into glycogen 2.7-fold and glucose oxidation 2.3-fold, whereas no effect on fructose incorporation into glycogen or fructose oxidation was noted. A physiological concentration of glucose (5 mM) decreased the rate of 0.5 mM fructose incorporation into glycogen by 60% (P < 0.001), whereas fructose oxidation was not altered in the presence of 5 mM glucose. Irrespective of fructose concentration, the majority of fructose taken up underwent non-oxidative metabolism. Lactate production accounted for approx. 80% of the fructose metabolism in the basal state and approx. 70% in the insulin (1000 mu-units/ml)-stimulated state. In the presence of 5 mM glucose, physiological concentrations of fructose could account for approximately 10-30% of hexose (glucose + fructose) incorporation into glycogen under non-insulin-stimulated conditions. In conclusion, fructose appears to be transported into human skeletal muscle via a carrier-mediated system that does not involve GLUT4 or GLUT1. Furthermore, under physiological conditions, fructose can significantly contribute to carbohydrate metabolism in human skeletal muscle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.