ArticleThe American journal of pathology1995
Expression of matrix proteinases during human intrahepatic bile duct development. A possible role in biliary cell migration.
Article in The American journal of pathology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 65 citations in OpenAlex.
- Concentration of Serum Matrix Metalloproteinase-3 in Patients With Primary Biliary Cholangitis.Frontiers in immunology · 2022Article
- A case of small hepatocellular carcinoma with malignant ductular reaction.International journal of clinical and experimental pathology · 2020Article
- A Retrospective Case Control Study of Ductal Plate Malformation-like Features in Consecutive 200 Autopsies.Pathology oncology research : POR · 2018Article
- Human ductal plate and its derivatives express antigens of cholangiocellular, hepatocellular, hepatic stellate/progenitor cell, stem cell, and neuroendocrine lineages, and proliferative antigens.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Noninvasive Intracystic Oncocytic Papillary Neoplasm of the Gall Bladder.Journal of gastrointestinal cancer · 2016Article
- Hepatobiliary cystadenocarcinoma of the liver with features of ductal plate malformations.Journal of gastrointestinal cancer · 2015Article
- Ontogenic development of nerve fibers in human fetal livers: an immunohistochemical study using neural cell adhesion molecule (NCAM) and neuron-specific enolase (NSE).Histochemistry and cell biology · 2015Article
- Human fetal ductal plate revisited: II. MUC1, MUC5AC, and MUC6 are expressed in human fetal ductal plate and MUC1 is expressed also in remodeling ductal plate, remodeled ductal plate and mature bile ducts of human fetal livers.International journal of clinical and experimental pathology · 2013Article
- Combined hepatocellular-cholangiocarcinoma with stem cell features, ductal plate malformation subtype: a case report and proposal of a new subtype.International journal of clinical and experimental pathology · 2013Article
- Ductal plate in hepatoblasts in human fetal livers: I. ductal plate-like structures with cytokeratins 7 and 19 are occasionally seen within human fetal hepatoblasts.International journal of clinical and experimental pathology · 2013Article
- Cutaneous pseudolymphoma: a case report with an immunohistochemical study.International journal of clinical and experimental pathology · 2013Article
- Malignant intraductal oncocytic papillary neoplasm of the common bile duct.International journal of clinical and experimental pathology · 2012Article
- High serum matrix metalloproteinase-3 and liver stiffness in postoperative biliary atresia.Pediatric surgery international · 2011Article
- Monolobar hepatobiliary fibropolycystic disease.Pathology oncology research : POR · 2011Article
- Heterotopic Pancreatic Tissue of the Stomach: Report of Three Cases and Consideration of Its Histogenesis.Case reports in gastroenterology · 2010Article
- Experience of a single center with congenital hepatic fibrosis: a review of the literature.World journal of gastroenterology · 2010Review
- A trypsin-like protease with apparent dual function in early Lepeophtheirus salmonis (Krøyer) development.BMC molecular biology · 2009Article
- Liver progenitor cells develop cholangiocyte-type epithelial polarity in three-dimensional culture.Molecular biology of the cell · 2007Article
- Mediation of transforming growth factor-beta(1)-stimulated matrix contraction by fibroblasts: a role for connective tissue growth factor in contractile scarring.The American journal of pathology · 2003Article
- Wound healing in the liver with particular reference to stem cells.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1998Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primitive biliary cells are known to migrate from the ductal plate into the mesenchyme during human intrahepatic bile duct development, and this migration process is essential for normal development of intrahepatic bile ducts. However, its molecular mechanism is unknown. Matrix proteinases play an important role in cell migration during cancer invasion and organ development. In this study, we therefore investigated in situ expression of matrix metalloproteinases (MMP) and tissue inhibitors of MMP (TIMP) during human intrahepatic bile duct development, using 32 human fetal livers. We also examined in situ expression of trypsinogen/trypsin, chymotrypsinogen/chymotrypsin, and cathepsin B, which are matrix proteinases and activators of MMP. MMP-1 expression was noted in the ductal plate and migrating primitive biliary cells. MMP-2, MMP-3, and MMP-9 were expressed in the ductal plate. TIMP-1 and TIMP-2 were expressed in the ductal plate and migrating primitive biliary cells. Trypsinogen/trypsin, chymotrypsinogen/chymotrypsin, and cathepsin B were also expressed in primitive biliary cells. These data suggest that MMP, trypsinogen/trypsin, chymotrypsinogen/chymotrypsin, and cathepsin B play a critical role in biliary cell migration during human intrahepatic bile duct development by degrading extracellular matrix proteins. The data also suggest that MMP inhibitors (TIMP-1 and TIMP-2) and MMP activators (trypsin, chymotrypsin, and cathepsin B) play an important role in biliary cell migration. The coordinated expression of MMP, MMP inhibitors, and MMP activators may be necessary for the normal development of human intrahepatic bile ducts.
Indexed as
Identifiers
7485384PMC1869511W1647145872What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.