ReviewThe American journal of pathology1995
gamma-Glutamyl transpeptidase. What does the organization and expression of a multipromoter gene tell us about its functions?
Review in The American journal of pathology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 123 citations in OpenAlex.
- The association of plasma levels of liver enzymes and risk of gestational diabetes mellitus: a systematic review and dose-response meta-analysis of observational studies.Acta diabetologica · 2020Pooled it
- Potential association between periodontitis and liver function test abnormalities: Results from the National Health and Nutrition Examination Survey (NHANES) 2009-2014.Journal of dental sciences · 2025Article
- Oxidative, Genotoxic and Epigenotoxic Effects of Pimpla turionellae Venom at Pharmacological Perspective.Neotropical entomology · 2025Article
- Clinical characteristics of choledochal cysts with intrahepatic bile duct dilatations: an observational study.Annals of surgical treatment and research · 2024Article
- Gamma-Glutamyl Transferase (γ-GT) - an old dog with new tricks?Liver international : official journal of the International Association for the Study of the Liver · 2022Review
- ω-Imidazolyl-alkyl derivatives as new preclinical drug candidates for treating non-alcoholic steatohepatitis.Physiological reports · 2021Article
- In vivo detection of γ-glutamyl-transferase up-regulation in glioma using hyperpolarized γ-glutamyl-[1-Scientific reports · 2020Article
- Lysophospholipid acyltransferases and leukotriene biosynthesis: intersection of the Lands cycle and the arachidonate PI cycle.Journal of lipid research · 2019Review
- Article
- Role of bacterial γ-glutamyltranspeptidase as a novel virulence factor in bone-resorbing pathogenesis.Journal of microbiology (Seoul, Korea) · 2016Article
- Osteodystrophy in Cholestatic Liver Diseases Is Attenuated by Anti-γ-Glutamyl Transpeptidase Antibody.PloS one · 2015Article
- Pregravid liver enzyme levels and risk of gestational diabetes mellitus during a subsequent pregnancy.Diabetes care · 2014Article
- Maternal bias and escape from X chromosome imprinting in the midgestation mouse placenta.Developmental biology · 2014Article
- Development of purine-derived 18F-labeled pro-drug tracers for imaging of MRP1 activity with PET.Journal of medicinal chemistry · 2014Article
- Gamma-glutamyl transpeptidase: redox regulation and drug resistance.Advances in cancer research · 2014Review
- Relationship between gamma-glutamyl transferase and glucose intolerance in first degree relatives of type 2 diabetics patients.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2011Article
- The seed composition of Arabidopsis mutants for the group 3 sulfate transporters indicates a role in sulfate translocation within developing seeds.Plant physiology · 2010Article
- Arsenite causes down-regulation of Akt and c-Fos, cell cycle dysfunction and apoptosis in glutathione-deficient cells.Journal of cellular biochemistry · 2010Article
- Formation of a vitamin C conjugate of acrolein and its paraoxonase-mediated conversion into 5,6,7,8-tetrahydroxy-4-oxooctanal.Chemical research in toxicology · 2010Article
- Ascorbic acid promotes detoxification and elimination of 4-hydroxy-2(E)-nonenal in human monocytic THP-1 cells.Chemical research in toxicology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
gamma-Glutamyl transpeptidase is a key enzyme in glutathione (GSH) salvage, metabolism of endogenous mediators such as leukotrienes and prostaglandins, detoxification of xenobiotics including environmentally important compounds and carcinogens, and cellular processes dependent on the oxidation/reduction of glutathione. The enzyme is widely distributed, and these functions often occur in separate tissues and in response to different stimuli. Evidence indicates that gamma-glutamyl transpeptidase plays a direct role in some hepatic and renal responses to injury. In the mouse gamma-glutamyl transpeptidase is a single copy gene expressed from at least seven promoters, and many of the transcribed gamma-glutamyl transpeptidase RNAs are restricted in their expression. Studies that combine analyses of cellular processes with a knowledge of gene structure and expression hold promise for unravelling how these two different levels of function are integrated.
Indexed as
Identifiers
7485380PMC1869519W191239963What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.