ArticleAmerican journal of human genetics1995
Efficiency of typing unaffected relatives in an affected-sib-pair linkage study with single-locus and multiple tightly linked markers.
Article in American journal of human genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- The Generalized Relative Pairs IBD Distribution: Its Use in the Detection of Linkage.Frontiers in public health · 2016Article
- Genetic and functional evidence implicating DLL1 as the gene that influences susceptibility to visceral leishmaniasis at chromosome 6q27.The Journal of infectious diseases · 2011Article
- Article
- Genes at human chromosome 5q31.1 regulate delayed-type hypersensitivity responses associated with Leishmania chagasi infection.Genes and immunity · 2007Article
- Article
- Y chromosome lineage- and village-specific genes on chromosomes 1p22 and 6q27 control visceral leishmaniasis in Sudan.PLoS genetics · 2007Article
- Genome-wide scan for visceral leishmaniasis susceptibility genes in Brazil.Genes and immunity · 2007Article
- Stage 2 of the Wellcome Trust UK-Irish bipolar affective disorder sibling-pair genome screen: evidence for linkage on chromosomes 6q16-q21, 4q12-q21, 9p21, 10p14-p12 and 18q22.Molecular psychiatry · 2005Article
- Evidence for a cluster of genes on chromosome 17q11-q21 controlling susceptibility to tuberculosis and leprosy in Brazilians.Genes and immunity · 2004Article
- A systematic genomewide linkage study in 353 sib pairs with schizophrenia.American journal of human genetics · 2003Article
- A genome screen for linkage in Australian sibling-pairs with multiple sclerosis.Genes and immunity · 2002Article
- Genetic analysis of multicase families of visceral leishmaniasis in northeastern Brazil: no major role for class II or class III regions of HLA.Genes and immunity · 2002Article
- A genome-wide screen for linkage in Nordic sib-pairs with multiple sclerosis.Genes and immunity · 2002Article
- The Wellcome trust UK-Irish bipolar affective disorder sibling-pair genome screen: first stage report.Molecular psychiatry · 2002Article
- The Siblings With Ischemic Stroke Study (SWISS) protocol.BMC medical genetics · 2002Article
- A genomewide screen for autism: strong evidence for linkage to chromosomes 2q, 7q, and 16p.American journal of human genetics · 2001Article
- A genomewide screen for autism susceptibility loci.American journal of human genetics · 2001Article
- The T cell regulator gene SH2D2A contributes to the genetic susceptibility of multiple sclerosis.Genes and immunity · 2001Article
- Association and linkage of leprosy phenotypes with HLA class II and tumour necrosis factor genes.Genes and immunity · 2001Article
- A genome screen for multiple sclerosis in Italian families.Genes and immunity · 2001Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In an affected-sib-pair study, the parents are often unavailable for typing, particularly for diseases of late onset. In many cases, however, it is possible to sample unaffected siblings. It is therefore desirable to assess the contribution of such siblings to the power of such a study. The likelihood ratio introduced by Risch and improved by Holmans was extended to incorporate data from unaffected siblings. Tests based on two likelihoods were considered: the full likelihood of the data, based on the identity-by-descent (IBD) sharing states of the entire sibship, and a pseudolikelihood based on the IBD sharing states of the affected pair only, using the unaffected siblings to infer parental genotypes. The latter approach was found to be more powerful, except when penetrance was high. Typing an unaffected sibling, or just one parent, was found to give only a small increase in power except when the PIC of the marker was low. Even then, typing an unaffected relative increased the overall number of individuals that had to be typed to achieve a given power. If there is no highly informative marker locus in the area under study, it may be possible to "build" one by combining the alleles from two or more neighboring tightly linked loci into haplotypes. Typing two loci gave a sizeable power increase over a single locus, but typing further loci gave much smaller gains. Building haplotypes will introduce phase uncertainties, with the result that such a system will yield less power than will a single locus with the same number of alleles. This power loss was small, however, and did not affect the conclusions regarding the worth of typing unaffected relatives.
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