ArticleAmerican journal of human genetics1995
Comparative genomic hybridization in clinical cytogenetics.
Article in American journal of human genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 119 citations in OpenAlex.
- Noninvasive prenatal diagnosis targeting fetal nucleated red blood cells.Journal of nanobiotechnology · 2022Review
- Scanning all chromosomal abnormalities with microarray-based comparative genomic hybridization in differential diagnosis of pediatric cancers.International journal of clinical and experimental pathology · 2019Article
- Personalized genomic medicine with a patchwork, partially owned genome.The Yale journal of biology and medicine · 2007Article
- Comparative genomic hybridisation in malignant deciduoid mesothelioma.Journal of clinical pathology · 2006Article
- The role of fluorescence in situ hybridization technologies in molecular diagnostics and disease management.Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology · 2000Review
- Comparative genomic hybridization in combination with flow cytometry improves results of cytogenetic analysis of spontaneous abortions.American journal of human genetics · 2000Article
- Applications of comparative genomic hybridisation in constitutional chromosome studies.Journal of medical genetics · 1999Article
- Confined placental mosaicism and intrauterine fetal growth.Archives of disease in childhood. Fetal and neonatal edition · 1998Review
- Mosaic supernumerary ring chromosome 19 identified by comparative genomic hybridisation.Journal of medical genetics · 1998Article
- Genetic analysis using genomic representations.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- A new strategy for cryptic telomeric translocation screening in patients with idiopathic mental retardation.Journal of medical genetics · 1998Article
- Chromosome specific comparative genome hybridisation for determining the origin of intrachromosomal duplications.Journal of medical genetics · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report the results of applying comparative genomic hybridization (CGH) in a cytogenetic service laboratory for (1) determination of the origin of extra and missing chromosomal material in intricate cases of unbalanced aberrations and (2) detection of common prenatal numerical chromosome aberrations. A total of 11 fetal samples were analyzed. Seven cases of complex unbalanced aberrations that could not be identified reliably by conventional cytogenetics were successfully resolved by CGH analysis. CGH results were validated by using FISH with chromosome-specific probes. Four cases representing common prenatal numerical aberrations (trisomy 21, 18, and 13 and monosomy X) were also successfully diagnosed by CGH. We conclude that CGH is a powerful adjunct to traditional cytogenetic techniques that makes it possible to solve clinical cases of intricate unbalanced aberrations in a single hybridization. CGH may also be a useful adjunct to screen for euchromatic involvement in marker chromosomes. Further technical development may render CGH applicable for routine aberration screening.
Indexed as
Identifiers
7485173PMC1801381W1508623892What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.