ArticleProceedings of the National Academy of Sciences of the United States of America1995
Evidence for synaptotagmin as an inhibitory clamp on synaptic vesicle release in Aplysia neurons.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 43 citations in OpenAlex.
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- Neurotrophic factors and target-specific retrograde signaling interactions define the specificity of classical and neuropeptide cotransmitter release at identified Lymnaea synapses.Scientific reports · 2020Article
- Article
- Complexins: small but capable.Cellular and molecular life sciences : CMLS · 2015Review
- Transmembrane tethering of synaptotagmin to synaptic vesicles controls multiple modes of neurotransmitter release.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The cytoplasmic domain of rat synaptotagmin I enhances synaptic transmission.Cellular and molecular neurobiology · 2014Article
- Article
- Differential regulation of transmitter release by alternatively spliced forms of synaptotagmin I.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Properties and plasticity of paired-pulse depression at a central synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Inhibition of quantal release from motor nerve by wortmannin.British journal of pharmacology · 1999Article
- Molecular diversity in neurosecretion: reflections on the hypothalamo-neurohypophysial system.Cellular and molecular neurobiology · 1998Review
- A novel seizure-induced synaptotagmin gene identified by differential display.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
While previous studies have demonstrated that synaptotagmin plays an essential role in evoked neurotransmitter release, it has been difficult to determine whether it acts to facilitate or inhibit release. To address this question, we used acute genetic manipulations to alter the expression of synaptotagmin in Aplysia neurons. Transient overexpression of synaptotagmin in acutely dissected cholinergic neurons and in cultured glutaminergic neurons decreased the amplitude of the excitatory postsynaptic potential (EPSP) by 32% and 26%, respectively. In contrast, treatment of cultured presynaptic neurons with synaptotagmin antisense oligonucleotides increased the amplitude of the EPSP by 50-75%. These results are consistent with a role of synaptotagmin as an inhibitor of release.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.