ArticleProceedings of the National Academy of Sciences of the United States of America1995
Neurotrophin 3 rescues neuronal precursors from apoptosis and promotes neuronal differentiation in the embryonic metanephric kidney.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 50 citations in OpenAlex.
- Functional Connections Between Insulin and Neurotrophin-3 in Hemodialysis Patients with Type 2 Diabetes.Current issues in molecular biology · 2026Review
- Serum Behavior of NT-3 and VEGFβ, Two Unstudied Growth Factors in Patients with Diabetes Mellitus and End-Stage Renal Disease.Journal of clinical medicine · 2025Article
- AAV1.NT3 gene therapy mitigates the severity of autoimmune encephalomyelitis in the mouse model for multiple sclerosis.Gene therapy · 2025Article
- Analysis of the Expression of Neurotrophins and Their Receptors in Adult Zebrafish Kidney.Veterinary sciences · 2022Article
- Growing a new human kidney.Kidney international · 2019Review
- Interferon-β Inhibits Neurotrophin 3 Signalling and Pro-Survival Activity by Upregulating the Expression of Truncated TrkC-T1 Receptor.Molecular neurobiology · 2017Article
- Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice.The Journal of clinical investigation · 2011Article
- Perturbation of cell cycle progression and cellular gene expression as a function of herpes simplex virus ICP0.Journal of virology · 1999Article
- The development of the kidney.Current topics in developmental biology · 1998Review
- Neurotrophin-3 is a survival factor in vivo for early mouse trigeminal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996Article
- Lack of neurotrophin-3 results in death of spinal sensory neurons and premature differentiation of their precursors.Neuron · 1996Article
- Development of the kidney medulla.OrganogenesisReview
- Expression of the neural stem cell markers NG2 and L1 in human angiomyolipoma: are angiomyolipomas neoplasms of stem cells?Molecular medicine (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We analyzed the developmental regulation and role of the neurotrophins during metanephric kidney morphogenesis. RNase protection assay revealed the presence of nerve growth factor, neurotrophin 3 (NT-3), and brain-derived neurotrophic factor mRNAs and the regulation of their expression during embryonic development of rat metanephros. NT-3 induced differentiation (neurite outgrowth) and survival (inhibition of apoptosis) of the neuronal precursors in cultured nephrogenic mesenchymes and neuronal differentiation in cultured whole kidneys, whereas NT-4/5, brain-derived neurotrophic factor, and nerve growth factor were without effect. The neurotrophins did not trigger tubular differentiation of isolated nephrogenic cells, which underwent apoptosis when cultured with or without the neurotrophins. NT-3 is thus an inducer of differentiation and a survival factor for renal neuronal cells, but none of the neurotrophins is a morphogen in kidney tubule induction.
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