ArticleProceedings of the National Academy of Sciences of the United States of America1995
Cloning of a sodium channel alpha subunit from rabbit Schwann cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 71 citations in OpenAlex.
- Alternative Splicing of the SLCO1B1 Gene: An Exploratory Analysis of Isoform Diversity in Pediatric Liver.Clinical and translational science · 2020Article
- DRG Voltage-Gated Sodium Channel 1.7 Is Upregulated in Paclitaxel-Induced Neuropathy in Rats and in Humans with Neuropathic Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Marked difference in saxitoxin and tetrodotoxin affinity for the human nociceptive voltage-gated sodium channel (Nav1.7) [corrected].Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Molecular differential expression of voltage-gated sodium channel α and β subunit mRNAs in five different mammalian cell lines.Journal of bioenergetics and biomembranes · 2011Article
- Dexmedetomidine and clonidine inhibit the function of Na(v)1.7 independent of α(2)-adrenoceptor in adrenal chromaffin cells.Journal of anesthesia · 2011Article
- Alternative splicing in the voltage-gated sodium channel DmNav regulates activation, inactivation, and persistent current.Journal of neurophysiology · 2009Article
- An emerging role for voltage-gated Na+ channels in cellular migration: regulation of central nervous system development and potentiation of invasive cancers.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2008Review
- Identification of the sensory neuron specific regulatory region for the mouse gene encoding the voltage-gated sodium channel NaV1.8.Journal of neurochemistry · 2008Article
- Article
- Voltage-gated Na+ channels: multiplicity of expression, plasticity, functional implications and pathophysiological aspects.European biophysics journal : EBJ · 2004Review
- Sensory and electrophysiological properties of guinea-pig sensory neurones expressing Nav 1.7 (PN1) Na+ channel alpha subunit protein.The Journal of physiology · 2003Article
- Expression and distribution of voltage-gated sodium channels in the cerebellum.Cerebellum (London, England) · 2003Review
- Alternative splicing of an insect sodium channel gene generates pharmacologically distinct sodium channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Glycosylation alters steady-state inactivation of sodium channel Nav1.9/NaN in dorsal root ganglion neurons and is developmentally regulated.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Novel point mutations in the German cockroach para sodium channel gene are associated with knockdown resistance (kdr) to pyrethroid insecticides.Insect biochemistry and molecular biology · 2000Article
- Slow closed-state inactivation: a novel mechanism underlying ramp currents in cells expressing the hNE/PN1 sodium channel.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Structure of the sodium channel gene SCN11A: evidence for intron-to-exon conversion model and implications for gene evolution.Molecular neurobiologyReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Overlapping cDNA clones spanning the entire coding region of a Na-channel alpha subunit were isolated from cultured Schwann cells from rabbits. The coding region predicts a polypeptide (Nas) of 1984 amino acids exhibiting several features characteristic of Na-channel alpha subunits isolated from other tissues. Sequence comparisons showed that the Nas alpha subunit resembles most the family of Na channels isolated from brain (approximately 80% amino acid identity) and is least similar (approximately 55% amino acid identity) to the atypical Na channel expressed in human heart and the partial rat cDNA, NaG. As for the brain II and III isoforms, two variants of Nas exist that appear to arise by alternative splicing. The results of reverse transcriptase-polymerase chain reaction experiments suggest that expression of Nas transcripts is restricted to cells in the peripheral and central nervous systems. Expression was detected in cultured Schwann cells, sciatic nerve, brain, and spinal cord but not in skeletal or cardiac muscle, liver, kidney, or lung.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.