ArticleProceedings of the National Academy of Sciences of the United States of America1995
exl protein specifically binds BLE1, a bicoid mRNA localization element, and is required for one phase of its activity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- The bicoid mRNA localization factor Exuperantia is an RNA-binding pseudonuclease.Nature structural & molecular biology · 2016Article
- Community effects in regulation of translation.eLife · 2016Article
- Drosophila Syncrip binds the gurken mRNA localisation signal and regulates localised transcripts during axis specification.Biology open · 2012Article
- Cis-acting determinants of asymmetric, cytoplasmic RNA transport.RNA (New York, N.Y.) · 2007Review
- Patterns of conservation and change in honey bee developmental genes.Genome research · 2006Article
- BSF binds specifically to the bicoid mRNA 3' untranslated region and contributes to stabilization of bicoid mRNA.Molecular and cellular biology · 2001Article
- Isolation of a ribonucleoprotein complex involved in mRNA localization in Drosophila oocytes.The Journal of cell biology · 2000Article
- Smaug, a novel and conserved protein, contributes to repression of nanos mRNA translation in vitro.RNA (New York, N.Y.) · 1999Article
- Mutational analysis of an RNA recognition element that mediates localization of bicoid mRNA.Molecular and cellular biology · 1998Article
- Characterization of a beta-actin mRNA zipcode-binding protein.Molecular and cellular biology · 1997Article
- Complex formation between stage-specific oocyte factors and a Xenopus mRNA localization element.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
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3 authors.
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Abstract
Localization of mRNAs, a crucial step in the early development of some animals, has been shown to be directed by cis-acting elements that presumably interact with localization factors. Here we identify a protein, exl, that binds to BLE1, an RNA localization element from the Drosophila bicoid mRNA. Using mutations in BLE1, we demonstrate a correlation between in vitro exl binding and one phase of in vivo localization directed by BLE1, implicating exl in that localization event. Furthermore, the same phase of localization is disrupted in exuperantia mutants, suggesting that exl and exuperantia proteins interact. Identification of a protein that binds specifically to an mRNA localization element and acts in mRNA localization opens the way for a biochemical analysis of this process.
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