ArticleProceedings of the National Academy of Sciences of the United States of America1995
Passive immunotherapy for retroviral disease: influence of major histocompatibility complex type and T-cell responsiveness.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 52 citations in OpenAlex.
- Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity.FEMS microbiology reviews · 2019Review
- Class switch recombination and somatic hypermutation of virus-neutralizing antibodies are not essential for control of friend retrovirus infection.Journal of virology · 2015Article
- Humoral immunity in the Friend retrovirus infection model.Immunologic research · 2013Review
- APOBEC3 versus Retroviruses, Immunity versus Invasion: Clash of the Titans.Molecular biology international · 2012Article
- In vivo imaging of virological synapses.Nature communications · 2012Article
- Distinct roles of CD4+ T cell subpopulations in retroviral immunity: lessons from the Friend virus mouse model.Retrovirology · 2011Review
- Immunology and the elusive AIDS vaccine.Nature · 2010Article
- Effects of acute and chronic murine norovirus infections on immune responses and recovery from Friend retrovirus infection.Journal of virology · 2009Article
- Retroviral immunology: lessons from a mouse model.Immunologic research · 2009Article
- B lymphocyte activation by coinfection prevents immune control of friend virus infection.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Endogenous cytotoxic T-cell response contributes to the long-term antiretroviral protection induced by a short period of antibody-based immunotherapy of neonatally infected mice.Journal of virology · 2008Article
- Suppression of acute anti-friend virus CD8+ T-cell responses by coinfection with lactate dehydrogenase-elevating virus.Journal of virology · 2008Article
- CD8+ T-cell dysfunction due to cytolytic granule deficiency in persistent Friend retrovirus infection.Journal of virology · 2005Article
- Induction of long-term protective antiviral endogenous immune response by short neutralizing monoclonal antibody treatment.Journal of virology · 2005Article
- New concepts in antibody-mediated immunity.Infection and immunity · 2004Review
- Essential role for virus-neutralizing antibodies in sterilizing immunity against Friend retrovirus infection.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Effective postexposure treatment of retrovirus-induced disease with immunostimulatory DNA containing CpG motifs.Journal of virology · 2002Article
- The antiviral activity of antibodies in vitro and in vivo.Advances in immunology · 2001Review
- Role of interleukin-4 (IL-4), IL-12, and gamma interferon in primary and vaccine-primed immune responses to Friend retrovirus infection.Journal of virology · 2001Article
- Major histocompatibility complex class I gene controls the generation of gamma interferon-producing CD4(+) and CD8(+) T cells important for recovery from friend retrovirus-induced leukemia.Journal of virology · 2000Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Administration of virus-specific antibodies is known to be an effective early treatment for some viral infections. Such immunotherapy probably acts by antibody-mediated neutralization of viral infectivity and is often thought to function independently of T-cell-mediated immune responses. In the present experiments, we studied passive antibody therapy using Friend murine leukemia virus complex as a model for an immunosuppressive retroviral disease in adult mice. The results showed that antibody therapy could induce recovery from a well-established retroviral infection. However, the success of therapy was dependent on the presence of both CD4+ and CD8+ T lymphocytes. Thus, cell-mediated responses were required for recovery from infection even in the presence of therapeutic levels of antibody. The major histocompatibility type of the mice was also an important factor determining the relative success of antibody therapy in this system, but it was less critical for low-dose than for high-dose infections. Our results imply that limited T-cell responsiveness as dictated by major histocompatibility genes and/or stage of disease may have contributed to previous immunotherapy failures in AIDS patients. Possible strategies to improve the efficacy of future therapies are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.