ArticleProceedings of the National Academy of Sciences of the United States of America1995
Interleukin 1 beta suppresses transforming growth factor-induced inorganic pyrophosphate (PPi) production and expression of the PPi-generating enzyme PC-1 in human chondrocytes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Whole Transcriptomic Analysis Identifies Candidate Biomarkers from Saliva of Temporomandibular Joint Osteoarthritis Patients.International journal of molecular sciences · 2026Article
- Systematic druggable genome-wide Mendelian randomization identifies therapeutic targets for calcium pyrophosphate deposition disease.Clinical rheumatology · 2025Article
- Follow the Molecule from Crystal Arthropathy to Comorbidities: The 2024 G-CAN Gold Medal Award Awardee Lecture.Gout, urate, and crystal deposition disease · 2025Article
- Elastic fiber alterations and calcifications in calcific uremic arteriolopathy.Scientific reports · 2023Article
- Histone Deacetylase Inhibitors Downregulate Calcium Pyrophosphate Crystal Formation in Human Articular Chondrocytes.International journal of molecular sciences · 2022Article
- "Lessons from Rare Forms of Osteoarthritis".Calcified tissue international · 2021Review
- Regulation and Role of TGFβ Signaling Pathway in Aging and Osteoarthritis Joints.Aging and disease · 2014Review
- Mono-allelic and bi-allelic ENPP1 deficiency promote post-injury neointimal hyperplasia associated with increased C/EBP homologous protein expression.Atherosclerosis · 2014Article
- Epigallocatechin-3-gallate reduces inflammation induced by calcium pyrophosphate crystals in vitro.Frontiers in pharmacology · 2013Article
- Hass avocado composition and potential health effects.Critical reviews in food science and nutrition · 2013Review
- Growth factors in the treatment of early osteoarthritis.Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases · 2013Article
- Npp1 promotes atherosclerosis in ApoE knockout mice.Journal of cellular and molecular medicine · 2011Article
- Pathophysiology of articular chondrocalcinosis--role of ANKH.Nature reviews. Rheumatology · 2011Review
- Cartilage biology, pathology, and repair.Cellular and molecular life sciences : CMLS · 2010Review
- The inorganic pyrophosphate transporter ANK preserves the differentiated phenotype of articular chondrocyte.The Journal of biological chemistry · 2010Article
- The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities.Endocrine reviews · 2008Review
- Inorganic pyrophosphate generation by transforming growth factor-beta-1 is mainly dependent on ANK induction by Ras/Raf-1/extracellular signal-regulated kinase pathways in chondrocytes.Arthritis research & therapy · 2007Article
- Calcium signalling and calcium transport in bone disease.Sub-cellular biochemistry · 2007Review
- Physiologic and pathologic functions of the NPP nucleotide pyrophosphatase/phosphodiesterase family focusing on NPP1 in calcification.Purinergic signalling · 2006Article
- Clinical manifestations and pathogenesis of hydroxyapatite crystal deposition in juvenile dermatomyositis.Current rheumatology reports · 2006Review
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Authors and funding
10 authors.
Funding
Abstract
Articular cartilage chondrocytes have the unique ability to elaborate large amounts of extracellular pyrophosphate (PPi), and transforming growth factor beta (TGF beta) appears singular among cartilage regulatory factors in stimulating PPi production. TGF beta caused a time and dose-dependent increase in intracellular and extracellular PPi in human articular chondrocyte cultures. TGF beta and interleukin 1 beta (IL-1 beta) antagonistically regulate certain chondrocyte functions. IL-1 beta profoundly inhibited basal and TGF beta-induced PPi elaboration. To address mechanisms involved with the regulation of PPi synthesis by IL-1 beta and TGF beta, we analyzed the activity of the PPi-generating enzyme NTP pyrophosphohydrolase (NTPPPH) and the PPi-hydrolyzing enzyme alkaline phosphatase. Human chondrocyte NTPPPH activity was largely attributable to plasma cell membrane glycoprotein 1, PC-1. Furthermore, TGF beta induced comparable increases in the activity of extracellular PPi, intracellular PPi, and cellular NTPPPH and in the levels of PC-1 protein and mRNA in chondrocytes as well as a decrease in alkaline phosphatase. All of these TGF beta-induced responses were completely blocked by IL-1 beta. Thus, IL-1 beta may be an important regulator of mineralization in chondrocytes by inhibiting TGF beta-induced PPi production and PC-1 expression.
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