ArticleProceedings of the National Academy of Sciences of the United States of America1995
Myc and Max: molecular evolution of a family of proto-oncogene products and their dimerization partner.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 79 citations in OpenAlex.
- Missense Mutations in Myc Box I Influence Nucleocytoplasmic Transport to Promote Leukemogenesis.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024Article
- Pheochromocytoma/Paraganglioma (PPGL): A Misdiagnosed Cause of Hypertension during Pregnancy.Case reports in obstetrics and gynecology · 2024Article
- Removal of evolutionarily conserved functional MYC domains in a tilapia cell line using a vector-based CRISPR/Cas9 system.Scientific reports · 2023Article
- MYC: a complex problem.Trends in cell biology · 2023Review
- Review
- Neuroprotective Gene Therapy by Overexpression of the Transcription Factor MAX in Rat Models of Glaucomatous Neurodegeneration.Investigative ophthalmology & visual science · 2022Article
- Yamanaka Factors in the Budding TunicateFrontiers in cell and developmental biology · 2022Article
- Oncogenes, tumor suppressor and differentiation genes represent the oldest human gene classes and evolve concurrently.Scientific reports · 2019Article
- MAX Mutations in Endometrial Cancer: Clinicopathologic Associations and Recurrent MAX p.His28Arg Functional Characterization.Journal of the National Cancer Institute · 2018Article
- Synchronous bilateral pheochromocytomas and paraganglioma with novel germline mutation in MAX: a case report.Surgical case reports · 2017Article
- Functional and in silico assessment of MAX variants of unknown significance.Journal of molecular medicine (Berlin, Germany) · 2015Article
- Article
- Cancer genomics and inherited risk.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2014Article
- Myc binds the pluripotency factor Utf1 through the basic-helix-loop-helix leucine zipper domain.Biochemical and biophysical research communications · 2013Article
- Exome sequencing identifies MAX mutations as a cause of hereditary pheochromocytoma.Nature genetics · 2011Article
- Evolution of the Max and Mlx networks in animals.Genome biology and evolution · 2011Article
- Analyses of domains and domain fusions in human proto-oncogenes.BMC bioinformatics · 2009Article
- Identification of internal ribosome entry segment (IRES)-trans-acting factors for the Myc family of IRESs.Molecular and cellular biology · 2008Article
- Assembly of b/HLH/z proteins c-Myc, Max, and Mad1 with cognate DNA: importance of protein-protein and protein-DNA interactions.Biochemistry · 2005Article
- Sequence signatures and the probabilistic identification of proteins in the Myc-Max-Mad network.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The myc gene family encodes a group of transcription factors that regulate cell proliferation and differentiation. These genes are widely studied because of their importance as proto-oncogenes. Phylogenetic analyses are described here for 45 Myc protein sequences representing c-, N-, L-, S-, and B-myc genes. A gene duplication early in vertebrate evolution produced the c-myc lineage and another lineage that later gave rise to the N- and L-myc lineages by another gene duplication. Evolutionary divergence in the myc gene family corresponds closely to the known branching order of the major vertebrate groups. The patterns of sequence evolution are described for five separate highly conserved regions, and these analyses show that differential rates of sequence divergence (= mosaic evolution) have occurred among conserved motifs. Further, the closely related dimerization partner protein Max exhibits significantly less sequence variability than Myc. It is suggested that the reduced variability in max stems from natural selection acting to preserve dimerization capability with products of myc and related genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.