ArticleProceedings of the National Academy of Sciences of the United States of America1995
Cloning and characterization of the Xenopus cyclin-dependent kinase inhibitor p27XIC1.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 103 citations in OpenAlex.
- Review
- Cell cycle control in the early embryonic development of aquatic animal species.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2015Review
- Retinoic acid signaling and neuronal differentiation.Cellular and molecular life sciences : CMLS · 2015Review
- aPKC phosphorylates p27Xic1, providing a mechanistic link between apicobasal polarity and cell-cycle control.Developmental cell · 2014Article
- Dysregulation of mTOR activity through LKB1 inactivation.Chinese journal of cancer · 2013Review
- Proteolysis of Xenopus Cip-type CDK inhibitor, p16Xic2, is regulated by PCNA binding and CDK2 phosphorylation.Cell division · 2013Article
- Developmental downregulation of Xenopus cyclin E is phosphorylation and nuclear import dependent and is mediated by ubiquitination.Developmental biology · 2011Article
- The CRL4Cdt2 ubiquitin ligase mediates the proteolysis of cyclin-dependent kinase inhibitor Xic1 through a direct association with PCNA.Molecular and cellular biology · 2010Article
- Self-regulation of Stat3 activity coordinates cell-cycle progression and neural crest specification.The EMBO journal · 2010Article
- Normal levels of p27 are necessary for somite segmentation and determining pronephric organ size.Organogenesis · 2009Article
- The Xenopus cell cycle: an overview.Molecular biotechnology · 2008Review
- The E3 ubiquitin ligase skp2 regulates neural differentiation independent from the cell cycle.Neural development · 2007Article
- Wee1 kinase alters cyclin E/Cdk2 and promotes apoptosis during the early embryonic development of Xenopus laevis.BMC developmental biology · 2007Article
- Undamaged DNA transmits and enhances DNA damage checkpoint signals in early embryos.Molecular and cellular biology · 2007Article
- Notch targets the Cdk inhibitor Xic1 to regulate differentiation but not the cell cycle in neurons.EMBO reports · 2006Article
- To proliferate or to die: role of Id3 in cell cycle progression and survival of neural crest progenitors.Genes & development · 2005Article
- An Ambystoma mexicanum EST sequencing project: analysis of 17,352 expressed sequence tags from embryonic and regenerating blastema cDNA libraries.Genome biology · 2004Article
- Two for two: Cdk2 and its role in centrosome doubling.Oncogene · 2002Review
- Xic1 degradation in Xenopus egg extracts is coupled to initiation of DNA replication.Genes & development · 2002Article
- p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis.The EMBO journal · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
We have isolated a gene encoding Xic-1, a 27-kDa cyclin-dependent kinase (Cdk) inhibitor from Xenopus ovary that shares significant homology with both mammalian CIP1 and Kip1/Kip2. The N- and C-terminal halves of Xic-1 are sufficient for interacting with Cdks and proliferating cell nuclear antigen, respectively. Recombinant Xic-1 inhibits Xenopus cyclin E/Cdk2, cyclin A/Cdk2 and cyclin B/Cdc2 activities, although with quite different IC50 values. Truncation of the N terminus of Xic-1 increases the IC50 value for cyclin A/Cdk2 50-fold with no effect on the inhibition of cyclin E/Cdk2 or cyclin B/Cdc2.Xic-1 inhibits both single-stranded and nuclear DNA synthesis in egg extracts, an effect reversed by proliferating cell nuclear antigen or cyclin E/Cdk2, respectively. These results suggest a function for Xic-1 in the control of DNA synthesis by cyclin E/Cdk2.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.