ArticleProceedings of the National Academy of Sciences of the United States of America1995
Nramp defines a family of membrane proteins.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.
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Who cites it
97 citing papers in PubMed.
- The SLC-ome of membrane transport: from molecular discovery to physiology and clinical applications.Physiological reviews · 2026Review
- Genome-wide identification of the NRAMP gene family in wheat and its ancestral species, and preliminary functional study ofFrontiers in plant science · 2026Article
- Screening and expression analysis of the NRAMP gene family in Kiwifruit under cadmium stress reveals the potential role of AcNRAMP7.BMC plant biology · 2025Article
- Genome-Wide analysis of the NRAMP gene family in Arabidopsis thaliana: identification, expression and response to multiple heavy metal stresses and phytohormones.BMC plant biology · 2025Article
- Sex-biased transcriptome in in vitro produced bovine early embryos.Cell & bioscience · 2025Article
- Host stress drives tolerance and persistence: The bane of anti-microbial therapeutics.Cell host & microbe · 2024Review
- Genome-Wide Identification and Expression Analysis Reveals Roles of theInternational journal of molecular sciences · 2023Article
- Key players in the regulation of iron homeostasis at the host-pathogen interface.Frontiers in immunology · 2023Review
- Zinc/iron-regulated transporter-like protein gene family inFrontiers in plant science · 2023Article
- Article
- Characterization of the NRAMP Gene Family in the Arbuscular Mycorrhizal FungusJournal of fungi (Basel, Switzerland) · 2022Article
- Effects of exogenous melatonin on expressional differences of immune-related genes in cashmere goats.Frontiers in genetics · 2022Article
- Molecular Mechanism of Nramp-Family Transition Metal Transport.Journal of molecular biology · 2021Review
- Genome-Wide Identification of theInternational journal of molecular sciences · 2021Article
- Divalent metal transporter-related protein restricts animals to marine habitats.Communications biology · 2021Article
- Effects of lysine and methionine in a low crude protein diet on the growth performance and gene expression of immunity genes in broilers.Poultry science · 2020Article
- Transcriptome profiling of Fagopyrum tataricum leaves in response to lead stress.BMC plant biology · 2020Article
- Mutation at Different Sites of Metal Transporter GeneFrontiers in plant science · 2019Article
- Genome-wide association study and candidate gene analysis of rice cadmium accumulation in grain in a diverse rice collection.Rice (New York, N.Y.) · 2018Article
- Characterization of Divalent Metal Transporter 1 (DMT1) in Brugia malayi suggests an intestinal-associated pathway for iron absorption.International journal for parasitology. Drugs and drug resistance · 2018Article
37 more citing papers are in PubMed but not listed here.
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7 authors.
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Abstract
Nramp (natural resistance-associated macrophage protein) is a newly identified family of integral membrane proteins whose biochemical function is unknown. We report on the identification of Nramp homologs from the fly Drosophila melanogaster, the plant Oryza sativa, and the yeast Saccharomyces cerevisiae. Optimal alignment of protein sequences required insertion of very few gaps and revealed remarkable sequence identity of 28% (yeast), 40% (plant), and 55% (fly) with the mammalian proteins (46%, 58%, and 73% similarity), as well as a common predicted transmembrane topology. This family is defined by a highly conserved hydrophobic core encoding 10 transmembrane segments. Other features of this hydrophobic core include several invariant charged residues, helical periodicity of sequence conservation suggesting conserved and nonconserved faces for several transmembrane helices, a consensus transport signature on the intracytoplasmic face of the membrane, and structural determinants previously described in ion channels. These characteristics suggest that the Nramp polypeptides form part of a group of transporters or channels that act on as yet unidentified substrates.
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