ArticleNucleic acids research1995
The purine-rich trinucleotide repeat sequences d(CAG)15 and d(GAC)15 form hairpins.
Article in Nucleic acids research, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Structural Study of DNA in Simulated Crowded Fluids.Chembiochem : a European journal of chemical biology · 2025Article
- Alternative DNA StructuresMicrobiology and molecular biology reviews : MMBR · 2021Review
- Molecular architecture of G-quadruplex structures generated on duplex Rif1-binding sequences.The Journal of biological chemistry · 2018Article
- A MutSβ-Dependent Contribution of MutSα to Repeat Expansions in Fragile X Premutation Mice?PLoS genetics · 2016Article
- Mutsβ generates both expansions and contractions in a mouse model of the Fragile X-associated disorders.Human molecular genetics · 2015Article
- Chromosomal directionality of DNA mismatch repair in Escherichia coli.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The mismatch repair protein MSH2 is rate limiting for repeat expansion in a fragile X premutation mouse model.Human mutation · 2014Article
- DNA mismatch repair complex MutSβ promotes GAA·TTC repeat expansion in human cells.The Journal of biological chemistry · 2012Article
- Chromatin changes in the development and pathology of the Fragile X-associated disorders and Friedreich ataxia.Biochimica et biophysica acta · 2012Review
- Evaluation of CAG repeat length of androgen receptor expressing cells in human testes showing different pictures of spermatogenic impairment.Histochemistry and cell biology · 2011Article
- Purification, crystallization and preliminary X-ray diffraction analysis of the human mismatch repair protein MutSβ.Acta crystallographica. Section F, Structural biology and crystallization communications · 2011Article
- Comparative genomics and molecular dynamics of DNA repeats in eukaryotes.Microbiology and molecular biology reviews : MMBR · 2008Review
- Folding of a DNA hairpin loop structure in explicit solvent using replica-exchange molecular dynamics simulations.Biophysical journal · 2007Article
- Article
- Transcription influences the types of deletion and expansion products in an orientation-dependent manner from GAC*GTC repeats.Nucleic acids research · 2004Article
- Slipped-strand DNAs formed by long (CAG)*(CTG) repeats: slipped-out repeats and slip-out junctions.Nucleic acids research · 2002Article
- Transcription and nuclear transport of CAG/CTG trinucleotide repeats in yeast.Nucleic acids research · 2002Article
- Modelling studies on neurodegenerative disease-causing triplet repeat sequences d(GGC/GCC)n and d(CAG/CTG)n.Journal of biosciences · 2001Article
- Conformational analysis of DNA-trinucleotide-hairpin-loop structures using a continuum solvent model.Biophysical journal · 2001Article
- Article
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3 authors.
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Abstract
The structures of single-stranded (ss) oligonucleotides containing (CAG)15 [ss(CAG)15] or (GAC)15 [ss(GAC)15] were examined. At 10 degrees C, the electrophoretic mobilites of the two DNAs were similar to ss(CTG)15, a DNA that forms a hairpin containing base paired and/or stacked thymines. At 37 degrees C in 50 mM NaCl, single-strand-specific P1 nuclease cleaved the G33-G36 phosphodiesters of ss(GAC)15, and the G32-A34, G35-C36 phosphodiesters of ss(CAG)15 (where the loop apex of both DNAs = A34). Electrophoretic mobility melting profiles indicated that the melting temperature (Tm) of ss(CAG)15 in low (approximately 1 mM Na+) ionic strength was 38 degrees C. In contrast, the Tm of ss(GAC)15 was 49 degrees C, a value similar to the Tm of ss(CTG)15. These results provide evidence that ss(GAC)15 and ss(CAG)15 form similar, but distinguishable hairpin structures.
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