ArticleNucleic acids research1995
Formation of a parallel-stranded DNA homoduplex by d(GGA) repeat oligonucleotides.
Article in Nucleic acids research, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Pentanucleotide guanine-rich WGGGW repeats, including CANVAS AGGGA repeats, form a variety of noncanonical structures.Nucleic acids research · 2026Article
- Thioflavin T binds dimeric parallel-stranded GA-containing non-G-quadruplex DNAs: a general approach to lighting up double-stranded scaffolds.Nucleic acids research · 2017Article
- Twisting right to left: A…A mismatch in a CAG trinucleotide repeat overexpansion provokes left-handed Z-DNA conformation.PLoS computational biology · 2015Article
- Selective association between nucleosomes with identical DNA sequences.Nucleic acids research · 2013Article
- Evaluation of effects of bivalent cations on the formation of purine-rich triple-helix DNA by ESI-FT-MS.Journal of the American Society for Mass Spectrometry · 2009Article
- Monitoring single-stranded DNA secondary structure formation by determining the topological state of DNA catenanes.Biophysical journal · 2006Article
- NMR structure of a parallel-stranded DNA duplex at atomic resolution.Nucleic acids research · 2002Article
- Triplex formation by morpholino oligodeoxyribonucleotides in the HER-2/neu promoter requires the pyrimidine motif.Nucleic acids research · 2001Article
- The roles of mutS, sbcCD and recA in the propagation of TGG repeats in Escherichia coli.Nucleic acids research · 2000Article
- Supramolecular self-assembly of d(TGG)4, synergistic effects of K+ and Mg2+.Biophysical journal · 1997Article
- Investigation of the formation and intracellular stability of purine.(purine/pyrimidine) triplexes.Nucleic acids research · 1997Article
- Enrichment of oligo(dG).oligo(dC)-containing fragments from human genomic DNA by Mg 2+-dependent triplex affinity capture.Nucleic acids research · 1997Article
- A novel activity of HMG domains: promotion of the triple-stranded complex formation between DNA containing (GGA/TCC)11 and d(GGA)11 oligonucleotides.Nucleic acids research · 1996Article
- A new approach to overcome potassium-mediated inhibition of triplex formation.Nucleic acids research · 1996Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The GGA9-H molecules consisting of a double helical stretch followed by a single-stranded 3'-terminal overhang of nine GGA sequence repeats exhibited a gel mobility-shifted band in a concentration-dependent manner, suggestive of the intermolecular complex formation. The position of the shifted band in a gel was almost identical to that of the Y-shaped dimer marker of the same molecular weight that had the two double-helices at one side. This suggests that GGA9-H dimerizes in a parallel orientation without the formation of four-stranded hairpin structure. Since the GGA9-H homoduplex was stably formed at pH 4, 7 and 9, the formation does not require protonation or deprotonation of the N1 position of adenines. Neither does it require the N7 group of guanines responsible for Hoogsteen base pairing from the methylation interference and modification studies. Modification of the N7 group of guanines with dimethyl sulfate (DMS) did not inhibit the association and also the N7 group in the homoduplex was not protected from DMS. On the other hand, the GAA9-H having the G to A base substitution did not show such an association with either GGA9-H or GAA9-H. These results suggest that the homoduplex formation may be due to G.G base pairing through non-Hoogsteen hydrogen bonds.
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