ArticleJournal of virology1995
Functional characterization of human immunodeficiency virus type 1 nef genes in patients with divergent rates of disease progression.
Article in Journal of virology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 65 citations in OpenAlex.
- HIV Nef Expression Down-modulated GFAP Expression and Altered Glutamate Uptake and Release and Proliferation in Astrocytes.Aging and disease · 2023Article
- An integrative genomic analysis of transcriptional profiles identifies characteristic genes and patterns in HIV-infected long-term non-progressors and elite controllers.Journal of translational medicine · 2019Article
- Weighted lambda superstrings applied to vaccine design.PloS one · 2019Article
- In vivo analysis of highly conserved Nef activities in HIV-1 replication and pathogenesis.Retrovirology · 2013Article
- Meta-analysis to test the association of HIV-1 nef amino acid differences and deletions with disease progression.Journal of virology · 2010Article
- Primary human immunodeficiency virus type 1 nef alleles show major differences in pathogenicity in transgenic mice.Journal of virology · 2007Article
- Article
- Nef alleles from human immunodeficiency virus type 1-infected long-term-nonprogressor hemophiliacs with or without late disease progression are defective in enhancing virus replication and CD4 down-regulation.Journal of virology · 2006Article
- Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef.Journal of virology · 2006Article
- Role of viral evolutionary rate in HIV-1 disease progression in a linked cohort.Retrovirology · 2005Article
- Human immunodeficiency virus type 1 superinfection was not detected following 215 years of injection drug user exposure.Journal of virology · 2004Article
- CD4 and major histocompatibility complex class I downregulation by the human immunodeficiency virus type 1 nef protein in pediatric AIDS progression.Journal of virology · 2003Article
- Inefficient enhancement of viral infectivity and CD4 downregulation by human immunodeficiency virus type 1 Nef from Japanese long-term nonprogressors.Journal of virology · 2002Article
- Nef-induced CD4 downregulation: a diacidic sequence in human immunodeficiency virus type 1 Nef does not function as a protein sorting motif through direct binding to beta-COP.Journal of virology · 2001Article
- Genetic and functional diversity of human immunodeficiency virus type 1 subtype B Nef primary isolates.Journal of virology · 2001Article
- Persistence of pathogenic challenge virus in macaques protected by simian immunodeficiency virus SIVmacDeltanef.Journal of virology · 2001Article
- The human immunodeficiency virus type 1 nef gene can to a large extent replace simian immunodeficiency virus nef in vivo.Journal of virology · 1999Article
- Sequence variations in human immunodeficiency virus type 1 Nef are associated with different stages of disease.Journal of virology · 1999Article
- Potential contributions of viral envelope and host genetic factors in a human immunodeficiency virus type 1-infected long-term survivor.Journal of virology · 1998Article
- Deletion of nef slows but does not prevent CD4-positive T-cell depletion in human immunodeficiency virus type 1-infected human-PBL-SCID mice.Journal of virology · 1997Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We have studied the sequence and function of the human immunodeficiency virus type 1 (HIV-1) nef genes from nine patients with highly divergent rates of disease progression enrolled in a longitudinal study of HIV disease. Over an average of 7.8 years of follow-up, three patients had net positive changes in CD4+ T-cell counts, three patients had net negative changes in CD4+ T cells but did not develop AIDS, and three patients progressed to AIDS. The nef gene from each of these patients was amplified and cloned, and the sequence of 8 to 10 clones was determined. Only 2 of 88 (2.3%) nef genes recovered from these nine patients were grossly defective. Moreover, there was no relationship between the phylogeny of nef sequences and the corresponding rates of disease progression from these patients. Representative nef genes from all nine patients were tested for their abilities to downregulate cell surface CD4 in a transient-transfection assay. There was no correlation found between the functions of the nef genes from these patients and their corresponding rates of disease progression. We conclude that the nef gene is not a common mediator of the rate of HIV disease progression in natural infection.
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