ArticleThe Journal of physiology1995
Ryanodine receptor-mediated intracellular calcium release in rat cerebellar Purkinje neurones.
Article in The Journal of physiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 146 citations in OpenAlex.
- Visual input drives diverse ER calcium signals in neuronsbioRxiv : the preprint server for biology · 2025Article
- Nernst-Planck-Gaussian finite element modelling of CaFrontiers in physiology · 2024Article
- Alexei Verkhratsky, the Philosopher of Neuroglia. Preface for the Honorary Issue of Neurochemical Research.Neurochemical research · 2023Article
- Compartment-specific tuning of dendritic feature selectivity by intracellular CaScience (New York, N.Y.) · 2022Article
- The spatio-temporal properties of calcium transients in hippocampal pyramidal neuronsFrontiers in cellular neuroscience · 2022Article
- Finite element analysis predicts CaScientific reports · 2021Article
- BK Channel Regulation of Afterpotentials and Burst Firing in Cerebellar Purkinje Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Is Purkinje Neuron Hyperpolarisation Important for Cerebellar Synaptic Plasticity? A Retrospective and Prospective Analysis.Cerebellum (London, England) · 2020Review
- The Origin of Physiological Local mGluR1 Supralinear CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Nitric Oxide-Induced Calcium Release: Activation of Type 1 Ryanodine Receptor, a Calcium Release Channel, through Non-Enzymatic Post-Translational Modification by Nitric Oxide.Frontiers in endocrinology · 2013Review
- Stress, caffeine and ethanol trigger transient neurological dysfunction through shared mechanisms in a mouse calcium channelopathy.Neurobiology of disease · 2013Article
- Functional integration of calcium regulatory mechanisms at Purkinje neuron synapses.Cerebellum (London, England) · 2012Review
- Ethanol alters opioid regulation of Ca(2+) influx through L-type Ca(2+) channels in PC12 cells.Alcoholism, clinical and experimental research · 2012Article
- Nitric oxide-induced calcium release via ryanodine receptors regulates neuronal function.The EMBO journal · 2012Article
- Altered calcium signaling following traumatic brain injury.Frontiers in pharmacology · 2012Article
- Parasagittally aligned, mGluR1-dependent patches are evoked at long latencies by parallel fiber stimulation in the mouse cerebellar cortex in vivo.Journal of neurophysiology · 2011Article
- Reduced expression of the Ca(2+) transporter protein PMCA2 slows Ca(2+) dynamics in mouse cerebellar Purkinje neurones and alters the precision of motor coordination.The Journal of physiology · 2010Article
- Abnormal calcium homeostasis in peripheral neuropathies.Cell calcium · 2010Review
- Low-frequency oscillations in the cerebellar cortex of the tottering mouse.Journal of neurophysiology · 2009Article
- Functional crosstalk between cell-surface and intracellular channels mediated by junctophilins essential for neuronal functions.Cerebellum (London, England) · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Ryanodine receptor-mediated Ca2+ release was investigated in Purkinje neurones of rat cerebellar slices by using whole-cell patch-clamp recordings combined with fluorometric digital imaging of cytoplasmic Ca2+ concentration ([Ca2+]i). 2. Caffeine caused a transient increase in [Ca2+]i in the somata and dendrites of Purkinje neurones. Caffeine-induced Ca2+ transients were not associated with a membrane inward current and persisted in Ca(2+)-free external solutions, indicating that they are caused by Ca2+ released from intracellular stores. The amplitudes of the caffeine-mediated elevations in [Ca2+]i were strongly dependent on the baseline level of [Ca2+]i. 3. Intracellular application of Ruthenium Red through the patch pipette blocked caffeine-induced Ca2+ transients in Purkinje neurones. Ryanodine when applied either intra- or extracellularly caused a use-dependent block of caffeine-induced Ca2+ release. 4. Depolarization-induced Ca2+ transients were strongly prolonged by caffeine. Several lines of evidence suggest that these prolongations reflect Ca(2+)-induced Ca2+ release. 5. Despite the presence of skeletal muscle type ryanodine receptors in Purkinje neurones, depolarizing pulses failed to induce any changes in [Ca2+]i when the influx of Ca2+ through voltage-gated channels was prevented by using Ca(2+)-free solution, or when applying blockers of voltage-gated Ca2+ channels. 6. Dendritic Ca2+ transients produced by stimulation of the excitatory climbing fibre synaptic input were also prolonged by caffeine, indicating that ryanodine receptor-mediated release of Ca2+ may be involved in synaptic signalling in cerebellar Purkinje neurones. 7. Ryanodine receptor-mediated release of Ca2+ in cerebellar Purkinje neurones can be explained by a model in which release of Ca2+ is strongly facilitated by the co-operative action of Ca2+, caffeine and/or ryanodine. Our results suggest that Ca2+ release in these central neurones becomes prominent only during episodes of intensive electrical activity associated with increased Ca2+ entry.
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