Trial reportThe Journal of physiology1995
Ingestion of branched-chain amino acids and tryptophan during sustained exercise in man: failure to affect performance.
Trial report in The Journal of physiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02019316 (The Effect of BioSteel Sports Drink Supplementation on Muscular Fatigue, Cognitive Function, and Recovery Following Sprint Interval Exercise), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of BioSteel Sports Drink Supplementation on Muscular Fatigue, Cognitive Function, and Recovery Following Sprint Interval Exercise
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 185 citations in OpenAlex.
- The Effect of Dietary Supplements on Endurance Exercise Performance and Core Temperature in Hot Environments: A Meta-analysis and Meta-regression.Sports medicine (Auckland, N.Z.) · 2021Pooled it
- Protein intake during training sessions has no effect on performance and recovery during a strenuous training camp for elite cyclists.Journal of the International Society of Sports Nutrition · 2016Trial
- Trial
- The effect of acute branched-chain amino acid supplementation on prolonged exercise capacity in a warm environment.European journal of applied physiology · 2004Trial
- The Effect of an Essential Amino Acid Supplement on Muscle Performance and Inflammation in an Animal Model of Overtraining.Nutrients · 2026Article
- Immune-proteo-metabolomic changes link to Aβ and tau pathology in Alzheimer disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Relevance and Safe Utilization of Amino Acids in Supplements for Human Nutrition: Lessons from Clinical and Preclinical Studies.Nutrients · 2026Review
- Preliminary Study on the Association of Serum Branched-Chain Amino Acids With Lipid and Hepatic Markers.Cardiology research · 2023Article
- Dietary Supplementation With Branched Chain Amino Acids to Improve Sleep in Veterans With Traumatic Brain Injury: A Randomized Double-Blind Placebo-Controlled Pilot and Feasibility Trial.Frontiers in systems neuroscience · 2022Article
- The athletic gut microbiota.Journal of the International Society of Sports Nutrition · 2020Review
- Restoration of Muscle Glycogen and Functional Capacity: Role of Post-Exercise Carbohydrate and Protein Co-Ingestion.Nutrients · 2018Review
- Effects of Glutamine and Alanine Supplementation on Central Fatigue Markers in Rats Submitted to Resistance Training.Nutrients · 2018Article
- Physical exercise-induced fatigue: the role of serotonergic and dopaminergic systems.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Review
- Article
- Changes in Serum Free Amino Acids and Muscle Fatigue Experienced during a Half-Ironman Triathlon.PloS one · 2015Article
- Performance Enhancing Diets and the PRISE Protocol to Optimize Athletic Performance.Journal of nutrition and metabolism · 2015Review
- Is it time to turn our attention toward central mechanisms for post-exertional recovery strategies and performance?Frontiers in physiology · 2015Review
- Exercise, nutrition and the brain.Sports medicine (Auckland, N.Z.) · 2014Review
- Is there a need for protein ingestion during exercise?Sports medicine (Auckland, N.Z.) · 2014Review
- Dietary supplements and team-sport performance.Sports medicine (Auckland, N.Z.) · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. An increased uptake of tryptophan in the brain may increase serotoninergic activity and recently has been suggested to be a cause of fatigue during prolonged exercise. The present study, therefore, investigates whether ingestion of tryptophan or the competing branched-chain amino acids (BCAAs) affect performance. Ten endurance-trained male athletes were studied during cycle exercise at 70-75% maximal power output, while ingesting, ad random and double-blind, drinks that contained 6% sucrose (control) or 6% sucrose supplemented with (1) tryptophan (3 g l-1), (2) a low dose of BCAA (6 g l-1) or (3) a high dose of BCAA (18 g l-1). 2. These treatments greatly increased the plasma concentration of the respective amino acids. Using the kinetic parameters of transport of human brain capillaries, BCAA supplements were estimated to reduce brain tryptophan uptake at exhaustion by 8-12%, while tryptophan ingestion caused a 7- to 20-fold increase. Exercise time to exhaustion was not different between treatments (122 +/- 3 min). 3. The data suggest that manipulation of tryptophan supply to the brain either has no additional effect upon serotoninergic activity during prolonged exhaustive exercise or that manipulation of serotoninergic activity functionally does not contribute to mechanisms of fatigue.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.