ArticleThe Journal of physiology1995
Burst kinetics of single NMDA receptor currents in cell-attached patches from rat brain cortical neurons in culture.
Article in The Journal of physiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.Pharmacological reviews · 2021Review
- NMDA receptors: linking physiological output to biophysical operation.Nature reviews. Neuroscience · 2017Review
- Gating reaction mechanism of neuronal NMDA receptors.Journal of neurophysiology · 2012Article
- Modes of glutamate receptor gating.The Journal of physiology · 2012Review
- Apoptosis and the receptor specificity of its mechanisms during the neurotoxic action of glutamate.Neuroscience and behavioral physiology · 2009Article
- Amantadine inhibits NMDA receptors by accelerating channel closure during channel block.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Protons trap NR1/NR2B NMDA receptors in a nonconducting state.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Capsaicin activation of the pain receptor, VR1: multiple open states from both partial and full binding.Biophysical journal · 2003Article
- Free intracellular Mg(2+) concentration and inhibition of NMDA responses in cultured rat neurons.The Journal of physiology · 2001Article
- Open channel block and alteration of N-methyl-D-aspartic acid receptor gating by an analog of phencyclidine.Biophysical journal · 1998Article
- Kinetic structure of large-conductance Ca2+-activated K+ channels suggests that the gating includes transitions through intermediate or secondary states. A mechanism for flickers.The Journal of general physiology · 1998Article
- Inversion of Markov processes to determine rate constants from single-channel data.Biophysical journal · 1997Article
- A novel mechanism of activity-dependent NMDA receptor antagonism describes the effect of ifenprodil in rat cultured cortical neurones.The Journal of physiology · 1996Article
- Voltage-dependent interaction of open-channel blocking molecules with gating of NMDA receptors in rat cortical neurons.The Journal of physiology · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
1. The patch-clamp technique was used to record single-channel currents from cell-attached patches on rat brain cortical neurons in culture. The composition of the open and shut intervals during bursts of openings was studied in N-methyl-D-aspartate (NMDA) receptors exposed to 1 microM NMDA and 10 microM glycine at a membrane potential of -70 mV. 2. Open interval histograms were constructed for openings at each position (first, second, third, etc.) during all bursts. Distributions from openings two to five were fitted with similar (two or three) exponential components. The first opening from all bursts tended to be of shorter duration than the other openings. 3. Bursts were sorted according to the number of openings they contained and duration histograms were obtained for the openings at each position (one to five) during bursts of up to five openings. For bursts containing two or more openings, the distribution of open durations obtained at a given position were similar to each other regardless of the number of openings in the burst. 4. In bursts of two or more openings (up to five), duration histograms from the openings at each position in the burst were fitted with two or three exponential components that were similar for each opening. Bursts consisting of a single opening had a different distribution, having a relatively larger component of short duration. 5. Shut intervals during bursts were described by two exponential components with average time constants (and relative areas) (means +/- S.E.M.) of 0.06 +/- 0.01 ms (0.59 +/- 0.02) and 0.64 +/- 0.02 ms (0.41 +/- 0.02). Their distribution was independent of the numbers of openings in the bursts, their position within the burst, and the types of openings (long or short duration) contained within the burst. 6. These results suggest that each opening in bursts of two or more openings is kinetically similar to every other opening regardless of burst length. Analogously, each shut period during a burst was similar to every other. A kinetic model with three open and four closed intraburst states is shown to be consistent with these results for bursts of two or more openings.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.