ArticleClinical and experimental immunology1980
IgE-dependent adherence and cytotoxicity of rat spleen and peritoneal cells to Litomosoides carinii microfilariae.
Article in Clinical and experimental immunology, 1980. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 52 citations in OpenAlex.
- Dose-Dependent Prophylactic Efficacy of Filarial Antigens Glutathione-S-Transferase and Abundant Larval Transcript-2 againstThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2024Article
- Human filariasis-contributions of the Litomosoides sigmodontis and Acanthocheilonema viteae animal model.Parasitology research · 2021Review
- Trichinella spiralis: killing of newborn larvae by lung cells.Parasitology research · 2015Article
- A comprehensive, model-based review of vaccine and repeat infection trials for filariasis.Clinical microbiology reviews · 2013Review
- Nematodes and the spleen: an immunological relationship.Experientia · 1994Review
- Fc epsilon receptor II-positive macrophages and platelets: potent effector cells in allergy and defence against helminth parasites.Springer seminars in immunopathology · 1990Review
- IgG response of rats to the excretory-secretory products of Litomosoides carinii.Parasitology research · 1990Article
- IgE and immune defense mechanism.Clinical reviews in allergy · 1989Review
- Immunity to Litomosoides carinii in Mastomys natalensis. II. Effects of chemotherapeutically abbreviated and postpatent primary infections on challenges with various stages of the parasite.Zeitschrift fur Parasitenkunde (Berlin, Germany) · 1986Article
- The ability of microfilariae to evade in vitro cell-mediated cytotoxicity.Zeitschrift fur Parasitenkunde (Berlin, Germany) · 1986Article
- Effect of liposomal amphotericin B on murine macrophages and lymphocytes.Infection and immunity · 1985Article
- Brugia pahangi: serum-dependent cell-mediated reactions to sheathed and exsheathed microfilariae.Immunology · 1984Article
- Increased expression of the IgE Fc receptors on rat macrophages induced by elevated serum IgE levels.Immunology · 1984Article
- IgE-dependent cellular adhesion and cytotoxicity to Litomosoides carinii microfilariae--nature of effector cells.Clinical and experimental immunology · 1982Article
- Enhanced adhesion of rat neutrophils to Litomosoides carinii microfilariae in the presence of culture supernatants from mitogen-stimulated lymph node cells.Clinical and experimental immunology · 1981Article
- Macrophages: progress and problems.Clinical and experimental immunology · 1981Review
- Antibody-dependent cell-mediated effects in bancroftian filariasis.Immunology · 1981Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serum taken after the termination of microfilaraemia from rats infected with the filarial parasite Litomosoides carinii brought about adherence and cytotoxicity of normal rat spleen and peritoneal cells to microfilariae. The activity could be absorbed to, and eluted from, anti-rat IgE, but not anti-rat IgG, immunosorbent columns. Immune serum heated to 56 degrees C for 3 hr did not cause cellular adherence or cytotoxicity; the addition of fresh normal rat serum failed to restore activity. Fresh rat serum did, however, restore activity to immune serum which was inactive after being heated to 56 degrees C for 30 min. EDTA, EGTA and diethylcarbamazine inhibited adherence. It is concluded that IgE antibodies are responsible for cellular adherence and cytotoxicity and that complement may play a part, as yet undefined, in these reactions.
Indexed as
Identifiers
7438547PMC1536934W1441761193What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.