ArticleGut1980
Low serum levels of 1.25-dihydroxyvitamin D and histomorphometric evidence of osteomalacia after jejunoileal bypass for obesity.
Article in Gut, 1980. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 62 citations in OpenAlex.
- Regulation of Renal and Extrarenal Calcitriol Synthesis and Its Clinical Implications.International journal of molecular sciences · 2025Review
- Fracture risk following bariatric surgery: a population-based study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Article
- Severe osteomalacia caused by short bowel syndrome in a patient on long-term hemodialysis after parathyroidectomy.Journal of bone and mineral metabolism · 2011Article
- The serum level of fibroblast growth factor-23 and calcium-phosphate homeostasis in obese perimenopausal women.International journal of endocrinology · 2011Article
- True fractional calcium absorption is decreased after Roux-en-Y gastric bypass surgery.Obesity (Silver Spring, Md.) · 2006Article
- Small intestine bacterial overgrowth and metabolic bone disease.Digestive diseases and sciences · 2001Article
- Postgastrectomy osteomalacia with pseudofractures assessed by repeated bone scintigraphy.Annals of nuclear medicine · 1995Article
- Article
- Biliary excretion of radioactivity after intravenous administration of [3H]25-hydroxyvitamin D3 in man.Digestive diseases and sciences · 1986Article
- Parathyroid hormone and calcium metabolism in generalized scleroderma. Increased PTH level and secondary hyperparathyroidism in patients with aberrant calcifications. Prophylactic treatment of calcinosis.Archives of dermatological research · 1984Article
- Bone disease after jejuno-ileal bypass for morbid obesity.Postgraduate medical journal · 1983Article
- Mineral metabolism during prolonged oral calcium substitution after jejuno-ileal bypass for morbid obesity.Klinische Wochenschrift · 1982Article
- Article
- Delayed fracture healing following jejunoileal bypass surgery for obesity.Calcified tissue international · 1982Article
- Does bone change after biliopancreatic diversion?Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary TractArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Twenty-seven unselected patients were investigated three to eight years after jejunoileal bypass for morbid obesity. The serum levels of calcium, magnesium, and phosphorus, and the renal excretions of calcium and magnesium were reduced. The serum alkaline phosphatase levels were increased. The serum levels of the two vitamin D metabolites 25-hydroxyvitamin D (25-OHD) and 1.25-dihydroxyvitamin D (1.25-(OHD)2D) were reduced and inversely related to the increased serum levels of immunoreactive parathyroid hormones (iPTH). Serum 1.25-(OH)2D correlated positively and serum iPTH inversely with serum concentrations and renal excretion rates of calcium. Iliac crest bone biopsies after in vivo tetracycline double-labelling showed a reduced bone turnover with an increased amount of osteoid due to an increase in both surface extent and mean width of osteoid seams. The increased volume of osteoid was caused by a decreased osteoblastic function with a longer life-span of bone-forming sites and a prolongation of the mineralisation lag time. The amount of trabecular bone was normal. The results indicate an impaired vitamin D metabolism with osteomalacia and secondary hyperparathyroidism.
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Registered trials
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