ArticleThe Journal of cell biology1980
Brush-border alpha-actinin? Comparison of two proteins of the microvillus core with alpha-actinin by two-dimensional peptide mapping.
Article in The Journal of cell biology, 1980. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Carbachol regulation of rabbit ileal brush border Na+-H+ exchanger 3 (NHE3) occurs through changes in NHE3 trafficking and complex formation and is Src dependent.The Journal of physiology · 2004Article
- Characterization of intestinal microvillar membrane disks: detergent-resistant membrane sheets enriched in associated brush border myosin I (110K-calmodulin).The Journal of cell biology · 1989Article
- Immuno-electron microscopical localisation of alpha-actinin and actin in microvilli of prostatic epithelial cells.Journal of anatomy · 1988Article
- Assembly of the intestinal brush border: appearance and redistribution of microvillar core proteins in developing chick enterocytes.The Journal of cell biology · 1987Article
- Proteins of the human placental microvillar cytoskeleton. alpha-Actinin.The Biochemical journal · 1986Article
- Characterization of the 110-kdalton actin-calmodulin-, and membrane-binding protein from microvilli of intestinal epithelial cells.The Journal of cell biology · 1983Article
- Partial reconstruction of the microvillus core bundle: characterization of villin as a Ca++-dependent, actin-bundling/depolymerizing protein.The Journal of cell biology · 1982Article
- alpha-Actinin and membrane glycoprotein IIIa are different proteins in human blood platelets.Proceedings of the National Academy of Sciences of the United States of America · 1982Article
- Immunoelectron microscope studies of membrane-microfilament interactions: distributions of alpha-actinin, tropomyosin, and vinculin in intestinal epithelial brush border and chicken gizzard smooth muscle cells.The Journal of cell biology · 1981Article
- Isolation and characterization of desmosome-associated tonofilaments from rat intestinal brush border.The Journal of cell biology · 1981Article
- Regulation of microvillus structure: calcium-dependent solation and cross-linking of actin filaments in the microvilli of intestinal epithelial cells.The Journal of cell biology · 1980Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The bundle of filaments within the intestinal microvillus contains four major polypeptides in addition to actin calmodulin, a 70-kdalton subunit and two polypeptides with molecular masses similar to that of the Z-line component alpha-actinin (95 and 105 kdaltons). Two-dimensional mapping of tryptic peptides indicates that (a) alpha-actinins from chicken skeletal, cardiac, and smooth muscle are similar but not identical proteins and that skeletal alpha-actinin in more similar to the cardiac subunit than to the alpha-actinin from gizzard; (b) the brush-border 95- and 105-kdalton subunits are closely related to each other, but the smaller subunit is not a proteolytic fragment of the 105-kdalton subunit; and (c) although there is considerable peptide overlap between the brush-border subunits and the three alpha-actinins, the peptide maps of the 95- and 105-kdalton proteins are substantially distinct from the various alpha-actinin maps, suggesting that neither brush-border subunit is a bona fide alpha-actinin. Nevertheless, on the basis of peptide mapping criteria alone, one cannot exclude the possibility that the brush-border subunits are "alpha-actinin-like." However, there is no immunological cross-reactivity between the brush-border subunits and alpha-actinins, using antibodies prepared against gizzard alpha actinin.
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