ArticleClinical and experimental immunology1981
Enhanced adhesion of rat neutrophils to Litomosoides carinii microfilariae in the presence of culture supernatants from mitogen-stimulated lymph node cells.
Article in Clinical and experimental immunology, 1981. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed, 3 citations in OpenAlex.
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microfilariae of the rat filarial parasite Litomosoides carinii are killed by normal rat neutrophils which adhere to them in the presence of antibody and complement. Adherence and killing were increased in the presence of the fluid from 48-hr cultures of Con A- or PHA-stimulated normal rat lymph node cells. Both normal and augmented binding were inhibited by cytochalasin B. The factor(s) responsible for increased binding was non-dialysable, susceptible to heat (56 degrees C, 30 min) and freezing and thawing. Its production was inhibited by cycloheximide. Pretreatment of neutrophils with stimulated culture supernatant for 3 hr, followed by washing, also augmented adherence. Similar pretreatment also enhanced phagocytosis of opsonized sheep erythrocytes and latex particles but did not increase candidacidal activity. These experiments suggest that cell-mediated immune reactions leading to lymphokine production may potentiate anti-filarial antibody-dependent cellular cytotoxicity and general phagocytosis by neutrophils.
Indexed as
Identifiers
7337966PMC1537397W2412846591What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.