ArticleThe Journal of cell biology1981
Mechanics of chromosome separation during mitosis in Fusarium (Fungi imperfecti): new evidence from ultrastructural and laser microbeam experiments.
Article in The Journal of cell biology, 1981. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 171 citations in OpenAlex.
- Shining Light in Mechanobiology: Optical Tweezers, Scissors, and Beyond.ACS photonics · 2024Review
- Coupling of microtubule bundles isolates them from local disruptions to set the structural stability of the anaphase spindle.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Mechanical Mechanisms of Chromosome Segregation.Cells · 2021Review
- Electron tomography reveals aspects of spindle structure important for mechanical stability at metaphase.Molecular biology of the cell · 2020Article
- Central-spindle microtubules are strongly coupled to chromosomes during both anaphase A and anaphase B.Molecular biology of the cell · 2019Article
- High-resolution imaging reveals how the spindle midzone impacts chromosome movement.The Journal of cell biology · 2019Article
- Mechanisms of Spindle Positioning: Lessons from Worms and Mammalian Cells.Biomolecules · 2019Review
- A review of "tethers": elastic connections between separating partner chromosomes in anaphase.Protoplasma · 2018Review
- Organization of microtubule assemblies in Dictyostelium syncytia depends on the microtubule crosslinker, Ase1.Cellular and molecular life sciences : CMLS · 2016Article
- Apical constriction: themes and variations on a cellular mechanism driving morphogenesis.Development (Cambridge, England) · 2014Review
- Cell cycle-regulated membrane binding of NuMA contributes to efficient anaphase chromosome separation.Molecular biology of the cell · 2014Article
- NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function.The EMBO journal · 2013Article
- The perpetual movements of anaphase.Cellular and molecular life sciences : CMLS · 2010Review
- Push-me-pull-you: how microtubules organize the cell interior.European biophysics journal : EBJ · 2008Review
- Dynein-mediated pulling forces drive rapid mitotic spindle elongation in Ustilago maydis.The EMBO journal · 2006Article
- Asymmetric spindle positioning.Current opinion in cell biology · 2006Review
- Boveri revisited.The EMBO journal · 2005Review
- The forces that position a mitotic spindle asymmetrically are tethered until after the time of spindle assembly.The Journal of cell biology · 2004Article
- The molecular function of Ase1p: evidence for a MAP-dependent midzone-specific spindle matrix. Microtubule-associated proteins.The Journal of cell biology · 2003Article
- CDK1 inactivation regulates anaphase spindle dynamics and cytokinesis in vivo.The Journal of cell biology · 1997Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The anaphase-telophase spindle usually elongates, and it has been assumed that the spindle pushes the incipient daughter nuclei apart. To test this assumption, we used a laser microbeam to sever the central spindle of the fungus, Fusarium solani, and measured the rate of separation of incipient daughter nuclei. When the microbeam was aimed beside the spindle separation occurred at a rate (8.6 micrometer/min) that did not differ significantly from the rate (7.6 micrometer/m) in unirradiated cells. But when the spindle was irradiated, it broke, and the separation was much faster (22.4 micrometer/min). Irradiation of cytoplasm lateral to one spindle pole resulted in a 1.5 micrometer/min reduction in the rate (6.1 micrometer/min) of separation. From these and other data, we infer that extranuclear forces, presumably involving astral microtubules, pull on the incipient daughter nuclei and that the central spindle limits the separation rate. Astral microtubules are associated with the plasma membrane or, sometimes, with the rough endoplasmic reticulum. Most of the spindle microtubules that are present at metaphase are depolymerized during anaphase and early telophase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.