ArticleInfection and immunity1981
Differences in resistance to Trypanosoma musculi infection among strains of inbred mice.
Article in Infection and immunity, 1981. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- Modulation of the Immune Response by Nematode Secreted Acetylcholinesterase Revealed by Heterologous Expression in Trypanosoma musculi.PLoS pathogens · 2016Article
- Immunological and nonimmunological control of severity of Trypanosoma musculi infections in C3H and C57BL/6 inbred mice.Infection and immunity · 1989Article
- Further characterization of the curative antibodies in Trypanosoma musculi infection.Infection and immunity · 1988Article
- The availability of purines influences both the number of parasites and the splenocyte levels of purine-metabolizing enzymes in trypanosome-infected mice.Infection and immunity · 1988Article
- Cooperative action of complement component C3 and phagocytic effector cells in innate murine resistance to Trypanosoma lewisi.Infection and immunity · 1987Article
- Characterization of antibodies mediating protection and cure of Trypanosoma musculi infection in mice.Infection and immunity · 1985Article
- Cure of Trypanosoma musculi infection by heat-labile activity in immune plasma.Infection and immunity · 1984Article
- Role of the H-2s haplotype in survival of mice after infection with Trypanosoma cruzi.Infection and immunity · 1984Article
- Age-associated impairment of murine natural killer activity.Proceedings of the National Academy of Sciences of the United States of America · 1983Article
- Effect of splenectomy on Trypanosoma lewisi infection in young rats.Infection and immunity · 1983Article
- Natural killer activity in mice infected with Trypanosoma musculi.Infection and immunity · 1983Article
- Immune responses to Candida albicans in genetically distinct mice.Infection and immunity · 1982Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inbred strains of mice were inoculated with Trypanosoma musculi, and the course of the ensuing parasitemia was followed. The mouse strains fell into three groups: those displaying high and moderate (fivefold less) parasitemia and C57BL/6 (B/6) mice which had exceptionally low infections. To gain insight concerning the mechanisms responsible for interstrain variations in infections, several types of experiments were performed. Comparison of the ability of spleen cells from the various strains to provide the growth-promoting substances required by T. musculi for growth in culture revealed that B/6 cells were deficient; this suggested one mechanism for regulating parasite infections. Exposure of C3H (high parasitemia) and B/6 mice to graded levels of ionizing radiation revealed that B/6 mice have much greater innate resistance to infection than do C3H mice. The effects of treating mice with silica dust or mercaptoethanol indicated that relative resistance to infection is not primarily associated with macrophage activity or limited growth-promoting substances. We conclude that variations in immune responsiveness to parasite antigens (probably not associated with the H-2 complex), possibly in concert with variations in a non-immunological mechanism, account for interstrain variation in resistance to T. musculi infections.
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