ArticleThe Journal of clinical investigation1981
Normotriglyceridemic abetalipoproteinemia. absence of the B-100 apolipoprotein.
Article in The Journal of clinical investigation, 1981. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 193 citations in OpenAlex.
- Guidelines for the diagnosis and management of chylomicron retention disease based on a review of the literature and the experience of two centers.Orphanet journal of rare diseases · 2010Guideline
- Human Vitamin E deficiency, and what is and is not Vitamin E?Free radical biology & medicine · 2024Review
- Mechanisms for the prevention of vitamin E excess.Journal of lipid research · 2013Review
- Molecular and metabolic basis for the metabolic disorder normotriglyceridemic abetalipoproteinemia.The Journal of clinical investigation · 1991Article
- A truncated species of apolipoprotein B (B67) in a kindred with familial hypobetalipoproteinemia.The Journal of clinical investigation · 1991Article
- Article
- Apolipoproteins in lipid transport, an impressionist view.Postgraduate medical journal · 1989Review
- Rat intestinal apolipoprotein B gene expression. Evidence for integrated regulation by bile salt, fatty acid, and phospholipid flux.The Journal of clinical investigation · 1988Article
- Characterization of an abnormal species of apolipoprotein B, apolipoprotein B-37, associated with familial hypobetalipoproteinemia.The Journal of clinical investigation · 1987Article
- Genetic analysis of a kindred with familial hypobetalipoproteinemia. Evidence for two separate gene defects: one associated with an abnormal apolipoprotein B species, apolipoprotein B-37; and a second associated with low plasma concentrations of apolipoprotein B-100.The Journal of clinical investigation · 1987Article
- The complete sequence and structural analysis of human apolipoprotein B-100: relationship between apoB-100 and apoB-48 forms.The EMBO journal · 1986Article
- Analysis of the apolipoprotein B gene and messenger ribonucleic acid in abetalipoproteinemia.The Journal of clinical investigation · 1986Article
- Epitopes of apolipoprotein B-100 and B-48 in both liver and intestine. Expression and evidence for local synthesis in recessive abetalipoproteinemia.The Journal of clinical investigation · 1986Article
- Hypobetalipoproteinemia with accumulation of an apoprotein B-like protein in intestinal cells. Immunoenzymatic and biochemical characterization of seven cases of Anderson's disease.The Journal of clinical investigation · 1986Article
- Apolipoprotein B synthesis by human liver and intestine in vitro.Proceedings of the National Academy of Sciences of the United States of America · 1986Article
- Vitamin E--its role in neurological function.Postgraduate medical journal · 1986Review
- Mapping of the human APOB gene to chromosome 2p and demonstration of a two-allele restriction fragment length polymorphism.Proceedings of the National Academy of Sciences of the United States of America · 1986Article
- Chromosomal localization of the human apolipoprotein B gene and detection of homologous RNA in monkey intestine.Proceedings of the National Academy of Sciences of the United States of America · 1986Article
- Molecular cloning of human apolipoprotein B cDNA.Nucleic acids research · 1985Article
- Molecular cloning and expression of partial cDNAs and deduced amino acid sequence of a carboxyl-terminal fragment of human apolipoprotein B-100.Proceedings of the National Academy of Sciences of the United States of America · 1985Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In the two genetic forms of abetalipoproteinemia described previously, recessive abetalipoproteinemia and homozygous hypobetalipoproteinemia, all lipoproteins that normally contain apolipoprotein B are absent from plasma. We describe here a new disorder in which normal low density and very low density lipoproteins are absent, but in which triglycerides are absorbed from the intestine and chylomicrons are present in plasma. The underlying molecular defect appears to be selective deletion of the hepatogenous B-100 apolipoprotein. The B-48 apolipoprotein found in chylomicrons is spared. These findings suggest that the two species of apolipoprotein B are under separate genetic control and that low density lipoproteins are not normally derived from chylomicrons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.