ArticleThe American journal of pathology1980
Subplasmalemmal linear densities in cells of the mononuclear phagocyte system in lung.
Article in The American journal of pathology, 1980. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 35 citations in OpenAlex.
- A National Heart, Lung, and Blood Institute history and perspective on lymphangioleiomyomatosis.Lymphatic research and biology · 2010Article
- Description of a new population of fixed macrophages in the splenic cords of pigs.Journal of anatomy · 1995Article
- Myocardial changes in acute Trypanosoma cruzi infection. Ultrastructural evidence of immune damage and the role of microangiopathy.The American journal of pathology · 1994Article
- Development of cytoplasmic digitations between Leydig cells and testicular macrophages of the rat.Cell and tissue research · 1992Article
- Specialised contacts of endoneurial fibroblasts with macrophages in wallerian degeneration.Journal of anatomy · 1986Article
- Experimental pulmonary candidiasis in modified rabbits. Histopathological, ultrastructural and enzyme cytochemical studies of tissue reactions.Mycopathologia · 1984Article
- Ultrastructural changes in bronchoalveolar lavage cells in sarcoidosis and comparison with the tissue granuloma.The American journal of pathology · 1983Article
- Hypersensitivity pneumonitis in man. Light- and electron-microscopic studies of 18 lung biopsies.The American journal of pathology · 1983Article
- Cells of the mononuclear phagocytic system resorb implanted bone matrix: a histologic and ultrastructural study.Calcified tissue international · 1982Article
- Globoid cell leukodystrophy: specialized contact of globoid cell with astrocyte in the brain of twitcher mouse.Acta neuropathologica · 1982Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The presence of subplasmalemmal linear densities in cells of the mononuclear phagocyte system was investigated in pulmonary biopsies from 33 patients with fibrotic lung disorders. Subplasmalemmal linear densities, consisting of a thin layer of electron-dense material immediately subjacent to the inner leaflet of the plasma membrane, were found in 30 of the 33 patients, including each of 6 patients with pulmonary sarcoidosis, 18 of 19 patients with idiopathic pulmonary fibrosis, 4 of 5 patients with collagen-vascular diseases, 1 patient with pulmonary lymphangioleiomyomatosis, and 1 patient with marked interstitial pulmonary fibrosis associated with squamous cell carcinoma of the lung. Subplasmalemmal linear densities were found in epithelioid cells, macrophages, and giant cells in granulomas in the 6 patients with sarcoidosis and in alveolar macrophages in 4 of these patients. In patients with other fibrotic lung disorders, subplasmalemmal linear densities were limited in distribution to interstitial and alveolar macrophages. In all patients with sarcoidosis some of the subplasmalemmal linear densities of adjacent mononuclear phagocytes, particularly of those in granulomas, were paired and formed specialized intercellular junctions. Such junctions also were observed in macrophages in 10 of the patients with other fibrotic lung disorders. The junctions formed by subplasmalemmal linear densities differed from other types of junctional structures. Subplasmalemmal linear densities appear to function in 1) the binding of action filalar junctions, which may contribute to the immobilization of mononuclear phagocytes in granulomas and alveolar lumens.
Indexed as
Identifiers
7190361PMC1903776W155204384What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.