ArticleThe EMBO journal1982
Actin filament capping protein from bovine brain.
Article in The EMBO journal, 1982. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 63 citations in OpenAlex.
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- CAPZA1 modulates EMT by regulating actin cytoskeleton remodelling in hepatocellular carcinoma.Journal of experimental & clinical cancer research : CR · 2017Article
- FtsZ filament capping by MciZ, a developmental regulator of bacterial division.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- CapZ and actin capping dynamics increase in myocytes after a bout of exercise and abates in hours after stimulation ends.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Proteomic analysis reveals differentially expressed proteins in the rat frontal cortex after methamphetamine treatment.Metabolic brain disease · 2009Article
- CapZ-lipid membrane interactions: a computer analysis.Theoretical biology & medical modelling · 2006Article
- A novel protein accumulated during maturation of the pods of the plant Impatiens balsamina.Molecular and cellular biochemistry · 1994Article
- Purification, characterization, and immunofluorescence localization of Saccharomyces cerevisiae capping protein.The Journal of cell biology · 1992Article
- Isolation and characterization of cDNA encoding the alpha subunit of Cap Z(36/32), an actin-capping protein from the Z line of skeletal muscle.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Cap Z(36/32), a barbed end actin-capping protein, is a component of the Z-line of skeletal muscle.The Journal of cell biology · 1987Article
- Studies on the transcription, translation, and structure of alpha-actinin in Dictyostelium discoideum.The Journal of cell biology · 1986Article
- Identification and localization of immunoreactive forms of caldesmon in smooth and nonmuscle cells: a comparison with the distributions of tropomyosin and alpha-actinin.The Journal of cell biology · 1985Article
- Cellular distribution of three mammalian Ca2+-binding proteins related to Torpedo calelectrin.The EMBO journal · 1984Article
- A 45,000-mol-wt protein-actin complex from unfertilized sea urchin egg affects assembly properties of actin.The Journal of cell biology · 1984Article
- New actin-binding proteins from Dictyostelium discoideum.The EMBO journal · 1984Article
- Acanthamoeba castellanii capping protein: properties, mechanism of action, immunologic cross-reactivity, and localization.The Journal of cell biology · 1984Article
- Treadmilling of actin.Journal of muscle research and cell motility · 1983Review
- 12-fold difference between the critical monomer concentrations of the two ends of actin filaments in physiological salt conditions.Proceedings of the National Academy of Sciences of the United States of America · 1983Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An actin filament capping protein has been purified from bovine brain. The protein has a native mol. wt. of 63 kilodaltons (kd) with subunits of 36 kd and 31 kd and is globular in shape. It nucleates actin polymerization, inhibits filament elongation and filament interactions, and decreases the steady state viscosity of F-actin in substoichiometric amounts (molar ration 1:1000). In addition, the protein increases the critical concentration for actin polymerization. Neither Ca2+ nor calmodulin affects it action. All these effects can be explained by the binding of the protein to the 'barbed' end of actin filaments leading to a blockade of actin monomer addition at the preferred growing end. This is directly demonstrated by electron microscopy. Concerning the polypeptide composition, Ca2+-independence, mode, and stoichiometry of actin interaction, the protein is similar to the capping protein, previously isolated from Acanthamoeba.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.