ArticleClinical and experimental immunology1982
Rat eosinophil-mediated antibody-dependent cellular cytotoxicity: investigations of the mechanisms of target cell lysis and inhibition by glucocorticoids.
Article in Clinical and experimental immunology, 1982. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 17 citations in OpenAlex.
- Emerging Evidence for Pleiotropism of Eosinophils.International journal of molecular sciences · 2021Review
- Eosinophils as Major Player in Type 2 Inflammation: Autoimmunity and Beyond.Advances in experimental medicine and biology · 2021Review
- Eosinophils in Autoimmune Diseases.Frontiers in immunology · 2017Review
- Two cases of acute myelitis with idiopathic hypereosinophilic syndrome.BMJ case reports · 2014Article
- Glucocorticoids inhibit granulocyte-macrophage colony-stimulating factor-1 and interleukin-5 enhanced in vitro survival of human eosinophils.Immunology · 1992Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purified eosinophils from the peritoneal washings of N. brasiliensis infected rats demonstrated antibody-dependent cellular cytotoxicity (ADCC) for 51Cr-labelled chicken erythrocytes. The F(ab')2 fragment of the antibody did not support cytotoxicity thereby demonstrating the importance of the eosinophil Fc receptor to this activity. Bystander lysis of erythrocytes did not occur, indicating that the eosinophil does not release lytic agents free into the medium. Cytochalasin B (1.25-5 micrograms/ml) colchicine (10(-5)-10(-3) M) and chloroquine (10(-4)-10(-3) M) inhibited eosinophil ADCC. Inhibition was also demonstrated by methylprednisolone, 10(-7)-10(-3) M and this inhibition was blocked by the protein synthesis inhibitor, cycloheximide (25 micrograms/ml). Cycloheximide alone had no effect. This block of steroid inhibition by cycloheximide suggests that the steroid effect on this system may be mediated by a newly synthesized protein and implies that the eosinophil may possess a glucocorticoid receptor.
Indexed as
Identifiers
7116688PMC1536620W126382959What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.