ReviewExperientia1982
Techniques and applications of extracellular space determination in mammalian tissues.
Review in Experientia, 1982. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed.
- Brain physiome: A concept bridgingBioactive materials · 2022Review
- Diffusion in the extracellular space in brain and tumors.Physical biology · 2013Article
- Article
- Microfiberoptic measurement of extracellular space volume in brain and tumor slices based on fluorescent dye partitioning.Biophysical journal · 2010Article
- Extracellular space volume measured by two-color pulsed dye infusion with microfiberoptic fluorescence photodetection.Biophysical journal · 2009Article
- Extracellular volume and blood volume in chronically catheterized fetal sheep.The Journal of physiology · 1995Article
- Pharmacokinetic analysis of drug absorption from muscle based on a physiological diffusion model: effect of molecular size on absorption.Pharmaceutical research · 1992Article
- A new method for assessment of drug disposition in muscle: application of statistical moment theory to local perfusion systems.Journal of pharmacokinetics and biopharmaceutics · 1985Article
- Intracellular pH in hibernation and respiratory acidosis in the European hamster.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 1985Article
- Asymmetric calcium influx and efflux at maternal and fetal sides of the guinea-pig placenta: kinetics and specificity.The Journal of physiology · 1984Article
- Rapid transcapillary exchange and unidirectional neuronal uptake of noradrenaline in the perfused rabbit heart.The Journal of physiology · 1984Article
- Estimation of hepatic distributional volumes using non-labeled reference markers.European journal of drug metabolism and pharmacokineticsArticle
- Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review summarizes the ways in which the extracellular space (ECS) may be estimated in mammalian tissues, and briefly describes some of the uses to which the EC confinement of certain molecules (markers or tracers) may be put in the elucidation of physiological functions. The introductory section is followed by a description of the more commonly used marker molecules and their functional characteristics, and of factors likely to lead to the spurious over- or under-estimation of the ECS. Certain alternative methods are also described, in particular those based on morphological and electrical criteria which seek to demonstrate small, functionally important, changes in the size of specialized regions of the ECS (e.g. lateral cellular interspaces) without necessarily being required to provide a quantitatively precise estimate of their size. Section III describes the results of measurements of ECS in various mammalian tissues (muscle, gastro-intestinal tract, nervous tissue, crystalline lens, placenta, lung and kidney) and some applications of EC markers to investigation of cellular function (e.g. uptake of metabolic substrates and epithelial transport) and, in outline, characterization of capillary permeability. The available literature in this field is very extensive, and in the interests of brevity the reader is, where appropriate, referred to previous reviews covering specialized aspects of ECS determination and related topics.
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7044812What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.