ArticleThe Journal of cell biology1982
Association between endocrine pancreatic secretory granules and in-vitro-assembled microtubules is dependent upon microtubule-associated proteins.
Article in The Journal of cell biology, 1982. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 111 citations in OpenAlex.
- Unveiling nanoscale optical signatures of cytokine-induced β-cell dysfunction.Scientific reports · 2023Article
- Microtubules Negatively Regulate Insulin Secretion in Pancreatic β Cells.Developmental cell · 2015Article
- Aged insulin granules display reduced microtubule-dependent mobility and are disposed within actin-positive multigranular bodies.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Targeted inactivation of kinesin-1 in pancreatic β-cells in vivo leads to insulin secretory deficiency.Diabetes · 2011Article
- Ultrastructural and immunocytochemical studies on the cytoskeleton in the anterior pituitary of rats, with special regard to the relationship between actin filaments and secretory granules.Cell and tissue research · 1989Article
- High-Mr microtubule-associated proteins: properties and functions.The Biochemical journal · 1989Review
- Formation of membrane networks in vitro by kinesin-driven microtubule movement.The Journal of cell biology · 1988Article
- Cytoskeletal-membrane interactions: a stable interaction between cell surface glycoconjugates and doublet microtubules of the photoreceptor connecting cilium.The Journal of cell biology · 1987Article
- Synapsin I: an actin-bundling protein under phosphorylation control.The Journal of cell biology · 1987Article
- Purification and characterization of a 190-kD microtubule-associated protein from bovine adrenal cortex.The Journal of cell biology · 1986Article
- Stable complexes of axoplasmic vesicles and microtubules: protein composition and ATPase activity.The Journal of cell biology · 1986Article
- Analysis of the spatial organization of microtubule-associated proteins.The Journal of cell biology · 1986Article
- 270K microtubule-associated protein cross-reacting with anti-MAP2 IgG in the crayfish peripheral nerve axon.The Journal of cell biology · 1986Article
- Microtubules and microtubule-associated proteins from the nematode Caenorhabditis elegans: periodic cross-links connect microtubules in vitro.The Journal of cell biology · 1986Article
- Cross-bridges mediate anterograde and retrograde vesicle transport along microtubules in squid axoplasm.The Journal of cell biology · 1985Article
- Cytoplasmic motions, rheology, and structure probed by a novel magnetic particle method.The Journal of cell biology · 1985Article
- Substrates for cyclic AMP-dependent protein kinase in islets of Langerhans. Studies with forskolin and catalytic subunit.The Biochemical journal · 1985Article
- Microtubule-associated protein 2 within axons of spinal motor neurons: associations with microtubules and neurofilaments in normal and beta,beta'-iminodipropionitrile-treated axons.The Journal of cell biology · 1985Article
- Secretory granules.Experientia · 1984Review
- Insulin secretion: the effector system.Experientia · 1984Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
By use of dark-field light microscopy, secretory granules isolated from the anglerfish endocrine pancreas were observed to attach to and release from microtubules assembled in vitro from brain homogenates. Secretory granules only bound to microtubules assembled in the presence of microtubule-associated proteins (MAPs) and not to microtubules assembled from purified tubulin. The addition of a MAP fraction to purified tubulin restored secretory granule binding. The secretory granules were released from MAP-containing microtubules by the addition of Mg-ATP but not by other nucleotides. The number of secretory granules bound to MAP-containing microtubules was increased in the presence of cyclic AMP. In addition to the associations of secretory granules with microtubules, MAP-containing microtubules also associated with each other. These laterally associated microtubules were dispersed by the addition of Mg-ATP. Electron micrographs confirmed that the associations between MAP-containing microtubules and secretory granules as well as the associations of microtubules with one another were mediated by the high molecular weight MAPs known to project from the surface of in-vitro-assembled microtubules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.