ArticleProceedings of the National Academy of Sciences of the United States of America1981
Chemical heterogeneity in cerebellar Purkinje cells: existence and coexistence of glutamic acid decarboxylase-like and motilin-like immunoreactivities.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1981. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 200 citations in OpenAlex.
- The role of GABAB receptors in the vestibular oculomotor system in mice.Behavioural brain research · 2016Article
- Irisin-immunoreactivity in neural and non-neural cells of the rodent.Neuroscience · 2013Article
- Cerebellar cortical molecular layer inhibition is organized in parasagittal zones.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Antigenic compartmentation of the primate and tree shrew cerebellum: a common topography of zebrin II in Macaca mulatta and Tupaia belangeri.Journal of anatomy · 2004Article
- Expression and possible role of neuronal calcium sensor-1 in the cerebellum.Cerebellum (London, England) · 2004Review
- Neurotransmitters, neuropeptides and calcium binding proteins in developing human cerebellum: a review.The Histochemical journal · 2000Review
- Ontogeny of GABA-immunoreactive cells in the primate cerebellar cortex: comparison with somatostatin-immunoreactivity.Anatomy and embryology · 1996Article
- Pyridoxal kinase immunoreactivity in rabbit brain.Neurochemical research · 1994Article
- Cerebellar degeneration in the Niemann-Pick type C mouse.Acta neuropathologica · 1993Article
- [3H]muscimol and [3H]flunitrazepam binding sites in the developing cerebellum of mice treated with methylazoxymethanol at different postnatal ages.Neurochemical research · 1992Article
- Expression of the yes proto-oncogene in cerebellar Purkinje cells.Molecular and cellular biology · 1989Article
- The distribution of GABA-like-immunoreactive neurons in the brain of the newt, Triturus cristatus carnifex, and the green frog, Rana esculenta.Cell and tissue research · 1989Article
- Somatostatin expression in the cerebellar cortex during postnatal development. An immunohistochemical study in the rat.Anatomy and embryology · 1989Article
- Light and electron microscopic studies on the localization of hyaluronic acid in developing rat cerebellum.The Journal of cell biology · 1988Article
- Coexistence of GABA- and choline acetyltransferase (ChAT)-like immunoreactivity in the hypoglossal nucleus of the rat.Histochemistry · 1988Article
- The neuropeptide cerebellin is a marker for two similar neuronal circuits in rat brain.Proceedings of the National Academy of Sciences of the United States of America · 1987Article
- Coexistence of peptides with classical neurotransmitters.Experientia · 1987Review
- gamma-Aminobutyric acid-containing terminals can be apposed to glycine receptors at central synapses.The Journal of cell biology · 1987Article
- In situ hybridization to localize mRNA encoding the neurotransmitter synthetic enzyme glutamate decarboxylase in mouse cerebellum.Proceedings of the National Academy of Sciences of the United States of America · 1986Article
- Is motilin a cerebellar peptide in the rat? A radioimmunological, chromatographic and immunohistochemical study.Anatomy and embryology · 1986Article
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7 authors at 3 institutions in 1 country.
Funding
Abstract
Purkinje neurons of the cerebellar cortex from a chemically and morphologically heterogeneous population containing some members that have gamma-aminobutyric acid (GABA), others that have immunoreactivity for motilin, and a small number that have both. The remaining 30-40% of all Purkinje cells have neither of these two neuroactive substances, leaving possibilities for other transmitter candidates. The evidence was compiled from double-staining immunocytochemical procedures performed on single sections of the cerebellum and brain stem in rat, mouse, and monkey. Two polyclonal antibodies were applied in succession, one directed against the midregion and COOH terminus of the 22-amino acid polypeptide motilin and the other against glutamic acid decarboxylase (glutamate decarboxylase; L-glutamate 1-carboxy-lyase, EC 4.1.1.15), the rate-limiting enzyme in the synthesis of the neurotransmitter GABA. The staining combinations employed the immunoperoxidase method, with different chromogens for distinguishing the motilin-like immunoreactivity from glutamic acid decarboxylase immunoreactivity by different colors, or the immunoperoxidase method for one antiserum and immunofluorescence for the other. The locations of both motilin and GABA cell types were mapped. The recognition of motilin in Purkinje cells calls for experimental definition of the role of this substance in the cerebellum and for reevaluation of the roles of Purkinje cells and of GABA in cerebellar function. The significant motilin representation in the flocculus, paraflocculus, and vermis suggests that it may be the Purkinje cell mediative chemical in the vestibular parts of the cerebellum. However, the presence of GABA as well in the same regions indicates that the chemical preference may be at least bimodal.
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