ArticleThe Journal of experimental medicine1981
Receptor for immunoglobulin Fc on pathogenic but not on nonpathogenic protozoa of the Trypanosomatidae.
Article in The Journal of experimental medicine, 1981. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Total serumiScience · 2023Article
- A transcriptome and proteome of the tick Rhipicephalus microplus shaped by the genetic composition of its hosts and developmental stage.Scientific reports · 2020Article
- The Fc Domain of Immunoglobulin Is Sufficient to Bridge NK Cells with Virally Infected Cells.Immunity · 2017Article
- Comment on "Regulation of immunity during visceral Leishmania infection" and further discussions about the role of antibodies in infections with Leishmania.Parasites & vectors · 2016Article
- Non-immune immunoglobulins shield Schistosoma japonicum from host immunorecognition.Scientific reports · 2015Article
- Haplotypes of the bovine IgG2 heavy gamma chain in tick-resistant and tick-susceptible breeds of cattle.Immunogenetics · 2011Article
- Herpesviral Fcgamma receptors: culprits attenuating antiviral IgG?International immunopharmacology · 2004Article
- Immunization strategies to block the herpes simplex virus type 1 immunoglobulin G Fc receptor.Journal of virology · 2004Article
- Cloning and characterization of a gene encoding an immunoglobulin-binding receptor on the cell surface of some members of the family Trypanosomatidae.Infection and immunity · 2003Article
- In vivo immune evasion mediated by the herpes simplex virus type 1 immunoglobulin G Fc receptor.Journal of virology · 1998Article
- An Fc gamma RII-, Fc gamma RIII-specific monoclonal antibody (2.4G2) decreases acute Trypanosoma cruzi infection in mice.Infection and immunity · 1993Article
- Herpes simplex virus type 1 Fc receptor protects infected cells from antibody-dependent cellular cytotoxicity.Journal of virology · 1991Article
- Binding of the specific ligand to Fc receptors on Trypanosoma cruzi increases the infective capacity of the parasite.Immunology · 1991Article
- A novel function of the herpes simplex virus type 1 Fc receptor: participation in bipolar bridging of antiviral immunoglobulin G.Journal of virology · 1989Article
- Fc receptors on the surface of Toxoplasma gondii trophozoites: a confounding factor in testing for anti-Toxoplasma antibodies by indirect immunofluorescence.Journal of clinical microbiology · 1989Article
- A surface glycoprotein of Trypanosoma lewisi binds immunoglobulin G from the serum of uninfected rats.Infection and immunity · 1986Article
- Binding of C3 fragments to the Trypanosoma cruzi surface in the absence of specific antibodies and without activation of the complement cascade.Clinical and experimental immunology · 1985Article
- Hypergammaglobulinaemia in Leishmania donovani infected hamsters: possible association with a polyclonal activator of B cells and with suppression of T cell function.Clinical and experimental immunology · 1985Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Members of the Trypanosomatidae were studied for their ability to acquire host IgG through a possible Fc receptor. A simple rosette test was devised in which the different species and forms of protozoa were mixed with SRBC sensitized with subagglutinating does of IgG, IgM, and F (ab') 2 anti-SRBC, and the pelleted mixture was observed for the number of clumps (rosettes) formed between the parasites and SRBC. Rosettes were formed between parasites and SRBC sensitized with IgG but not with IgM or F(ab')2, indicating the presence of a receptor for IgG Fc. The specificity of this receptor for Fc was confirmed by inhibition experiments with normal rabbit aggregated gammaglobulins or with purified normal rabbit Fc. The receptor is sensitive to treatment with trypsin but regenerates after a short period of incubation (1 h), which indicates that it is synthesized by the parasite itself. Interesting was the observation that only pathogenic members of the Trypanosomatidae formed rosettes with sensitized SRBC. In none of the nonpathogenic forms studied could we demonstrate the Fc receptor. Also important was the finding that freshly isolated blood stream forms of Trypanosoma cruzi from infected mice did not form rosettes. However, after trypsinization, these forms clearly displayed the ability to do so, possibly indicating a previous acquisition of the host IgG by the parasites in the mouse blood stream. These findings point to a possible and important means of parasite evasion of the host immune response by masking their surface with host IgG.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.