Evidence map›Paper›PMID 6999345›Full record

Trial reportThe New England journal of medicine1980

Influence of adherence to treatment and response of cholesterol on mortality in the coronary drug project.

Coronary Drug Project Research Group

Registry-linked trialAbstract readClinical TrialComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in The New England journal of medicine, 1980. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT00000482. Cited by 138 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed, 7 pooled it
27.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00000482 phase3completed

Coronary Drug Project

Ran1965Registered outcomes0Posted comparisons0ConditionsCardiovascular Diseases, Coronary Disease, Heart Diseases, Myocardial InfarctionArmsclofibrate clofibrate, dextrothyroxine sodium, Estrogen, niacin
PMID 4275188PMID 4320008PMID 4337170PMID 4356847PMID 4570454PMID 457827PMID 4610000PMID 6501718PMID 7002353PMID 7014029PMID 7094247PMID 7261627other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

138 citing papers in PubMed, 7 syntheses or guidelines pooled it, 656 citations in OpenAlex.

  1. Pooled it
  2. The effect of placebo adherence on reducing cardiovascular mortality: a meta-analysis.Clinical research in cardiology : official journal of the German Cardiac Society · 2014
    Pooled it
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  5. Efficacy of pneumococcal vaccination in adults: a meta-analysis.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2009
    Pooled it
  6. Dopamine agonist therapy in early Parkinson's disease.The Cochrane database of systematic reviews · 2008
    Pooled it
  7. Placebo effect in the treatment of duodenal ulcer.British journal of clinical pharmacology · 1999
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78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Coronary Drug Project Research Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Coronary Drug Project was carried out to evaluate the efficacy and safety of several lipid-influencing drugs in the long-term treatment of coronary heart disease. The five-year mortality in 1103 men treated with clofibrate was 20.0 per cent, as compared with 20.9 per cent in 2789 men given placebo (P = 0.55). Good adherers to clofibrate, i.e., patients who took 80 per cent of more of the protocol prescription during the five-year follow-up period, had a substantially lower five-year mortality than did poor adherers to clofibrate (15.0 vs. 24.6 per cent; P = 0.00011). However, similar findings were noted in the placebo group, i.e., 15.1 per cent mortality for good adherers and 28.3 per cent for poor adherers (P = 4.7x10-16). These findings and various other analyses of mortality in the clofibrate and placebo groups of the project show the serious difficulty, if not impossibility, of evaluating treatment efficacy in subgroups determined by patient responses (e.g., adherence or cholesterol change) to the treatment protocol after randomization.

Indexed as

Patient ComplianceAdultCholesterolClinical Trials as TopicClofibrateCoronary DiseaseFollow-Up StudiesHumansMaleMiddle AgedPrognosisRandom AllocationRiskTime FactorsCholesterolClofibrate

Identifiers

PMID6999345
OpenAlexW4230501493

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.