ArticleThe Journal of cell biology1980
Effect of microinjected N-ethylmaleimide-modified heavy meromyosin on cell division in amphibian eggs.
Article in The Journal of cell biology, 1980. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 38 citations in OpenAlex.
- The Rho GTP exchange factor Lfc promotes spindle assembly in early mitosis.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Identification of the gene for fly non-muscle myosin heavy chain: Drosophila myosin heavy chains are encoded by a gene family.The EMBO journal · 1989Article
- Cytokinesis is defective in Dictyostelium mutants with altered phagocytic recognition, adhesion, and vegetative cell cohesion properties.The Journal of cell biology · 1987Article
- Subcellular distribution of rhodamine-actin microinjected into living fibroblastic cells.The Journal of cell biology · 1983Article
- Analysis of the role of microtubules and actin in erythrophore intracellular motility.The Journal of cell biology · 1983Article
- N-ethylmaleimide-modified subfragment-1 and heavy meromyosin inhibit reactivated contraction in motile models of retinal cones.The Journal of cell biology · 1983Article
- Microinjection into an identified axon to study the mechanism of fast axonal transport.Proceedings of the National Academy of Sciences of the United States of America · 1982Article
- Evidence that myosin does not contribute to force production in chromosome movement.The Journal of cell biology · 1982Article
- Effects of exogenous proteins on cytoplasmic streaming in perfused Chara cells.The Journal of cell biology · 1982Article
- A permeabilized cell model for studying cell division: a comparison of anaphase chromosome movement and cleavage furrow constriction in lysed PtK1 cells.The Journal of cell biology · 1981Article
- A permeabilized cell model for studying cytokinesis using mammalian tissue culture cells.The Journal of cell biology · 1980Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
N-Ethylmaleimide-modified heavy meromyosin (NEM-HMM) microinjected into amphibian eggs inhibits cytokinesis and the cortical contractions associated with wound closure. Injection of NEM-HMM into two-cell Rana pipiens embryos produces a zone of cleavage inhibition around the point of injection. Early furrows followed by time-lapse microcinematography are seen to slow and stop as they enter the NEM-HMM-injected zone. Arrested furrows slowly regress, leaving a large region of cytoplasm uncleaved. Few nuclei are found in these regions of cleavage inhibition. Wound closure is often inhibited by NEM-HMM, especially when this inhibitor is injected just beneath the egg cortex. We observe that the surface of an unfertilized Rana egg is covered with microvilli that disappear during the course of development. The surfaces of NEM-HMM-inhibited zones remain covered with microvilli and resemble the unfertilized egg surface.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.