ArticleProceedings of the National Academy of Sciences of the United States of America1980
Inhibition of Ca2+ accumulation in mitogen-activated lymphocytes: role of membrane-bound plasma lipoproteins.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1980. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 34 citations in OpenAlex.
- Studies of gene variants related to inflammation, oxidative stress, dyslipidemia, and obesity: implications for a nutrigenetic approach.Journal of obesity · 2011Article
- The key role of apolipoprotein E in atherosclerosis.Journal of molecular medicine (Berlin, Germany) · 2005Review
- Modulation of human lymphocyte responses by low density lipoproteins (LDL): enhancement but not immunosuppression is mediated by LDL receptors.Proceedings of the National Academy of Sciences of the United States of America · 1984Article
- Increased lysolecithin acyltransferase activity in the plasma of type II hyperlipoproteinemic patients.Lipids · 1984Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Low density lipoproteins (LDL) in which apoB is the only protein constituent inhibit lymphocyte activation induced by the mitogen phytohemagglutinin. LDL suppress primary induction events, most notably enhanced Ca2+ accumulation, which occur as a result of mitogen-triggered alterations of the lymphocyte plasma membrane. Receptors in the lymphocyte membrane--designated "immunoregulatory receptors"--recognize and bind apoB-LDL. Under conditions of receptor saturation, about 22,500 +/- 4500 LDL particles are bound to the lymphocyte surface at 4 and 37 degrees C. The dissociation constant, Kd, is 1.76 X 10(-7) M and is also independent of temperature. Suppression of phytohemagglutinin-induced 45Ca2+ accumulation by LDL is a receptor-dependent process: inhibition is contingent on attachment of LDL to the immunoregulatory receptors. This conclusion is supported by three lines of evidence. First, heparin restores the susceptibility of the lymphocytes to mitogenic challenge by displacing membrane-bound LDL. Second, the immnoregulatory potency of LDL correlates directly with the amount of LDL bound at the cell surface. Third, LDL-Sepharose complexes, which cannot be internalized by the cells, are as immunosuppressive as soluble LDL. This demonstrates that membrane-bound plasma lipoproteins influence the behavior of intact cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.