Trial reportAntimicrobial agents and chemotherapy1983
Comparative pharmacokinetics of metronidazole and tinidazole as influenced by administration route.
Trial report in Antimicrobial agents and chemotherapy, 1983. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Clinical pharmacokinetics of metronidazole: a systematic review and meta-analysis.Antimicrobial agents and chemotherapy · 2025Pooled it
- Tinidazole vs metronidazole for the treatment of bacterial vaginosis: a systematic review and meta-analysis.Archives of gynecology and obstetrics · 2025Pooled it
- Efficacy and safety of different drugs for the treatment of bacterial vaginosis: a systematic review and network meta-analysis.Frontiers in cellular and infection microbiology · 2024Pooled it
- An open-source framework for physiologically-based pharmacokinetic modeling of kinetics in the female reproductive tract.Frontiers in pharmacology · 2026Article
- In Silico Evaluation of the Biopharmaceutical and Pharmacokinetic Behavior of Metronidazole from Coated Colonic Release Matrix Tablets.Pharmaceutics · 2025Article
- Is the GFR-based scaling approach adequate for predicting pediatric renal clearance of drugs with passive tubular reabsorption? Insights from PBPK modeling.CPT: pharmacometrics & systems pharmacology · 2025Article
- PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Metabolism in Pregnant Subjects and Fetuses.Pharmaceutics · 2024Article
- Distinct Changes in Microbiota-Mediated Intestinal Metabolites and Immune Responses Induced by Different Antibiotics.Antibiotics (Basel, Switzerland) · 2022Article
- Finding a Balance in the Vaginal Microbiome: How Do We Treat and Prevent the Occurrence of Bacterial Vaginosis?Antibiotics (Basel, Switzerland) · 2021Review
- Systemic and Target-Site Pharmacokinetics of Antiparasitic Agents.Clinical pharmacokinetics · 2020Review
- Metronidazole and hydroxymetronidazole central nervous system distribution: 1. microdialysis assessment of brain extracellular fluid concentrations in patients with acute brain injury.Antimicrobial agents and chemotherapy · 2014Article
- Treatment Strategies for Recurrent Clostridium difficile Infection.The Canadian journal of hospital pharmacy · 2013Review
- Prospective observational study comparing three different treatment regimes in patients with Clostridium difficile infection.Antimicrobial agents and chemotherapy · 2012Article
- A comparative study of oral single dose of metronidazole, tinidazole, secnidazole and ornidazole in bacterial vaginosis.Indian journal of pharmacology · 2012Article
- Tinidazole in the treatment of bacterial vaginosis.International journal of women's health · 2010Article
- Antibiotic consideration in bacterial vaginosis.Current infectious disease reports · 2009Article
- Guidelines for the treatment of bacterial vaginosis: focus on tinidazole.Therapeutics and clinical risk management · 2009Article
- Treatment of infections caused by metronidazole-resistant Trichomonas vaginalis.Clinical microbiology reviews · 2004Review
- Pharmacodynamic effects of nitroimidazoles alone and in combination with clarithromycin on Helicobacter pylori.Antimicrobial agents and chemotherapy · 2002Article
- Pharmacokinetics and pharmacodynamics of the nitroimidazole antimicrobials.Clinical pharmacokinetics · 1999Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serum kinetics of metronidazole and tinidazole were compared in four separate randomized crossover studies. Single doses of each drug were given to healthy volunteers through intravenous infusion (500 mg over 20 min, six persons), by mouth (500 mg, nine persons), by rectum (1,000 mg, six persons), or intravaginally (500 mg, six persons). Concentrations of the unchanged drugs in serum, measured by high-pressure liquid chromatography, were similar after oral and intravenous administration, with mean peaks of 9.0 and 9.4 micrograms/ml for metronidazole and 7.5 and 10.1 micrograms/ml for tinidazole. Concentrations of tinidazole were significantly higher than those of metronidazole from 4 h onwards after intravenous infusion, and from 3 h onwards after administration by mouth. After rectal administrations, a significant difference was seen only at 48 h. After vaginal dosing, however, concentrations of metronidazole were significantly higher than those of tinidazole between 1.5 and 12 h. Bioavailability of either drug, calculated according to the formula (area under the curve for oral administration)/(area under the curve for infusion), was practically complete after oral administration and was poorer after rectal and especially vaginal administration. Whenever the parameters were calculable, the elimination half-life of tinidazole (range of means, 14.0 to 14.7 h) was significantly longer and total clearance (40.3 to 47.6 ml/min) was lower than the corresponding values of metronidazole (7.9 to 8.8 h and 71.8 to 80.1 ml/min, respectively).
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