ArticleThe Journal of experimental medicine1983
Enhancement of human eosinophil-mediated killing of Schistosoma mansoni larvae by mononuclear cell products in vitro.
Article in The Journal of experimental medicine, 1983. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 89 citations in OpenAlex.
- Pilot Study on Interferon-γ-producing T Cell Subsets after the Protective Vaccination with Radiation-attenuated Cercaria of Schistosoma japonicum in the Miniature Pig Model.Tropical medicine and health · 2014Article
- Modulation of the Fc gamma RII and Fc gamma RIII induced by GM-CSF, IFN-gamma and IL-4 on murine eosinophils.Immunology · 1994Article
- Hypofibrinogenemia due to fibrin formation in subserosal type eosinophilic gastroenteropathy.The Clinical investigator · 1992Article
- Eosinophils: a review.Veterinary research communications · 1992Review
- Tumor necrosis factor alpha/cachectin stimulates eosinophil oxidant production and toxicity towards human endothelium.The Journal of experimental medicine · 1990Article
- Enhancement of leukotriene C4 release from primate airway macrophages by cellular interactions.British journal of pharmacology · 1989Article
- Eosinophil-activating factor (EAF) production by a human cell line (ESH 98) stimulated with tumour necrosis factor.Immunology · 1988Article
- Stimulation of proliferation, differentiation, and function of human cells by primate interleukin 3.Proceedings of the National Academy of Sciences of the United States of America · 1987Article
- The effects of eosinophil activating factor on IgG-dependent sulphidopeptide leukotriene generation by human eosinophils.Clinical and experimental immunology · 1986Article
- Recombinant human granulocyte-macrophage colony-stimulating factor stimulates in vitro mature human neutrophil and eosinophil function, surface receptor expression, and survival.The Journal of clinical investigation · 1986Article
- Presence of factors chemotactic for granulocytes in hypereosinophilic syndrome sera: relation with alterations in eosinophil migration.Clinical and experimental immunology · 1986Article
- Murine eosinophil differentiation factor. An eosinophil-specific colony-stimulating factor with activity for human cells.The Journal of experimental medicine · 1986Article
- Monoclonal antibodies to human eosinophil plasma membrane antigens enhance the secretion of eosinophil cationic protein.Clinical and experimental immunology · 1986Article
- Tumor necrosis factor enhances eosinophil toxicity to Schistosoma mansoni larvae.Proceedings of the National Academy of Sciences of the United States of America · 1986Article
- Eosinophils as effector cells in immunity and hypersensitivity disorders.Clinical and experimental immunology · 1985Review
- Ultrastructure of the attack of eosinophils stimulated by blood mononuclear cell products on schistosomula of Schistosoma mansoni.The American journal of pathology · 1985Article
- A cellular abnormality in glucocorticoid resistant asthma.Clinical and experimental immunology · 1985Article
- Plasma membrane antigens on light density and activated human blood eosinophils.Clinical and experimental immunology · 1985Article
- Inhibition of eosinophils degranulation by Ketotifen in a patient with milk allergy, manifested as bronchial asthma--an electron microscopic study.Agents and actions · 1984Article
- Surface proteins of the human eosinophil. II. Effects of Schistosoma mansoni larvae on eosinophil surface proteins.Clinical and experimental immunology · 1984Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have shown that eosinophils from eosinophilic individuals differ functionally from those of normal individuals. In order to test whether agents that might induce eosinophilia could also affect eosinophil function, we have compared the capacity of culture supernatants from mononuclear cells of eosinophilic or normal individuals to enhance eosinophil activity, as reflected by an increased killing of schistosomula of Schistosoma mansoni in vitro. An enhancing activity was detected, which increased both the antibody-dependent, and to some extent the antibody-independent killing of schistosomula by eosinophils, in the absence of complement. Under similar conditions, the supernatants failed to stimulate an otherwise undetectable neutrophil-mediated killing. The activity could be removed from the assay by washing, without reversing previous eosinophil stimulation, and was not directly toxic to the schistosomula. Preliminary characterization of the activity indicated that it was relatively heat-stable at 100 degrees C for 30 min, and had an estimated molecular weight of 35,000-45,000 as judged by G-200 Sephadex fractionation. The activity was produced by a nonlymphocytic, nonspecific esterase-containing adherent mononuclear cell in the absence of either Con A or antigenic stimulation. Significant enhancing activity was detectable after 1 h of culture and continued for at least 25 h. Protein synthesis was required for its production or release. Although the activity was detectable in supernatants from both eosinophilic and normal individuals, the supernatants that demonstrated highest activity and that could be titrated out furthest were generally derived from eosinophilic individuals, suggesting that there might be some association between eosinophilia and enhanced eosinophil function.
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