ArticleClinical and experimental immunology1983
Antigenic analysis of Brugia timori, a filarial nematode of man: initial characterization by surface radioiodination and evaluation of diagnostic potential.
Article in Clinical and experimental immunology, 1983. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 33 citations in OpenAlex.
- Impact ofTropical medicine and infectious disease · 2025Article
- Differential recognition of a protective filarial antigen by antibodies from humans with bancroftian filariasis.The Journal of clinical investigation · 1986Article
- Excretory-secretory and somatic antigens in the diagnosis of human filariasis.Clinical and experimental immunology · 1984Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The antigenic composition of Brugia timori has been investigated with surface labelling techniques and defined sets of parasite molecules have been identified on infective larvae, adult worms and microfilariae. Iodinated preparations from all three stages were assessed for immunodiagnostic potential with a small number of serum samples from human filariasis patients. In these tests, reaction with infective larval antigen was the clearest indicator of infection. Reactivity to microfilarial antigens however, correlated poorly with incidence of infection. These experiments show that levels of anti-parasite antibody appear to increase as filarial disease becomes more severe. In contrast to some reports, antibody to microfilarial surface antigens is present in sera from several patients with circulating microfilariae. The immunodiagnostic potential of these tests is indicated by the detection of a few individuals who have high levels of antibody but no outward signs of infection.
Indexed as
Identifiers
6839543PMC1536888W227814446What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.