ArticleThe American journal of pathology1983
Hypersensitivity pneumonitis in man. Light- and electron-microscopic studies of 18 lung biopsies.
Article in The American journal of pathology, 1983. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 152 citations in OpenAlex.
- The Occupational Burden of Nonmalignant Respiratory Diseases. An Official American Thoracic Society and European Respiratory Society Statement.American journal of respiratory and critical care medicine · 2019Review
- Stop Being So Sensitive: An Exceptionally Rare Report of Ustekinumab-Induced Sub-acute Hypersensitivity Pneumonitis.Turkish journal of anaesthesiology and reanimation · 2017Article
- Lymphangiogenic factors are associated with the severity of hypersensitivity pneumonitis.BMJ open respiratory research · 2015Article
- Small airways diseases, excluding asthma and COPD: an overview.European respiratory review : an official journal of the European Respiratory Society · 2013Article
- An unusual case of pneumonia.Internal and emergency medicine · 2008Article
- Hypersensitivity pneumonitis.Orphanet journal of rare diseases · 2006Review
- Article
- Type III hypersensitivity reaction in mushroom growers.The Korean journal of internal medicine · 1991Article
- Intraluminal fibrosis induced unilaterally by lobar instillation of CdCl2 into the rat lung.The American journal of pathology · 1990Article
- Intra-alveolar fibrosis of idiopathic bronchiolitis obliterans-organizing pneumonia. Cell-matrix patterns.The American journal of pathology · 1990Article
- Modulation of actin isoform expression in alveolar myofibroblasts (contractile interstitial cells) during pulmonary hypertension.The American journal of pathology · 1990Article
- Article
- Ultrastructural evidence of alveolar epithelial injury in idiopathic bronchiolitis obliterans-organizing pneumonia.The American journal of pathology · 1988Article
- Detection of antigen-specific antibodies on lung tissue in a patient with hypersensitivity pneumonitis.Virchows Archiv. A, Pathological anatomy and histopathology · 1988Article
- Two-hour methyl isocyanate inhalation and 90-day recovery study in B6C3F1 mice.Environmental health perspectives · 1987Article
- Article
- Intraluminal fibrosis in interstitial lung disorders.The American journal of pathology · 1986Article
- Article
- Histamine release from human basophils by pepstatin A.Agents and actions · 1985Article
- Patterns of pulmonary structural remodeling after experimental paraquat toxicity. The morphogenesis of intraalveolar fibrosis.The American journal of pathology · 1985Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Light- and electron-microscopic changes produced by hypersensitivity pneumonitis were analyzed in open lung biopsies taken from 18 patients with chronic forms of the disease. The main changes observed were: alveolitis (both luminal and mural), granulomas, intraalveolar buds, and interstitial fibrosis. The cells infiltrating the alveolar walls were mainly lymphocytes. Occasionally these lymphocytes presented irregularities in the contours of the nuclear membranes and resembled Sézary cells. In one patient, a few lymphocytes were found that resembled "hand-mirror" cells. Intraalveolar macrophages often had a foamy appearance. Granulomas, present in two-thirds of the patients, differed in several respects from those in sarcoidosis: they were smaller, more loosely arranged, and poorly limited; they had a higher content of lymphocytes; and they were located more frequently in alveolar tissue than in the vicinity of bronchioles and vessels. Intraalveolar buds, also present in about two thirds of the patients, were composed mainly of fibroblasts, myofibroblasts, and macrophages in a loose connective tissue that was rich in proteoglycan material. Capillaries and epithelial cells were rarely seen in buds. Alveolar buds appear to develop by a process of disruption of the epithelial lining layer, due to alveolitis, followed by intraalveolar exudation and by subsequent intraalveolar migration of connective tissue cells interacting with macrophages. Severe fibrotic and alveolar epithelial changes were observed in four patients; milder changes were frequent in most other patients. It is concluded that hypersensitivity pneumonitis usually has distinctive morphologic features; these may help to distinguish the resultant pulmonary fibrosis from that due to other causes.
Indexed as
Identifiers
6829707PMC1916173W1484285503What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.