ArticleDiabetes1982
Acetone metabolism during diabetic ketoacidosis.
Article in Diabetes, 1982. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05541484 (Ketone Monitoring in T1D), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Ketone Monitoring in T1D: Effect of SGLT2i During Usual Care and With Insulin Deficiency
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 180 citations in OpenAlex.
- Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus.Diabetes care · 2011Guideline
- Why hyperinsulinemia is detrimental to weight loss: insights from type 1 diabetes.BMC medicine · 2026Review
- Chemical Proteomics Identifies Ketogenesis-Mediated Cysteine Modifications Regulating Redox Function.Angewandte Chemie (International ed. in English) · 2026Article
- In vivo Detection and Correlation of Cerebral Ketone Bodies with Neurotransmitters in Streptozotocin-Induced Type 1 Diabetic Rats.Neurochemical research · 2025Article
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- Ultrasensitive sensing performances of amphiphilic block copolymer induced gyrus-like InRSC advances · 2023Article
- The Computational Acid-Base Chemistry of Hepatic Ketoacidosis.Metabolites · 2023Article
- A Strategy to Enhance Humidity Robustness of p-Type CuO Sensors for Breath Acetone Quantification.Small science · 2023Article
- Non-Invasive Disease Specific Biomarker Detection Using Infrared Spectroscopy: A Review.Molecules (Basel, Switzerland) · 2023Review
- Modulation of 1,2-Dicarbonyl Compounds in Postprandial Responses Mediated by Food Bioactive Components and Mediterranean Diet.Antioxidants (Basel, Switzerland) · 2022Review
- Interference of ketone bodies on laboratory creatinine measurement in children with DKA: a call for change in testing practices.Pediatric nephrology (Berlin, Germany) · 2022Article
- Article
- Highly Sensitive Electrochemical Sensor for Diagnosis of Diabetic Ketoacidosis (DKA) by Measuring Ketone Bodies in Urine.Sensors (Basel, Switzerland) · 2021Article
- Highly Sensitive Room-Temperature Sensor Based on Nanostructured K₂W₇OSensors (Basel, Switzerland) · 2018Article
- Acetone Sensing Properties and Mechanism of Rh-Loaded WOFrontiers in chemistry · 2018Article
- Enhanced Acetone Sensing Characteristics of ZnO/Graphene Composites.Sensors (Basel, Switzerland) · 2016Article
- Effects of urine composition on epithelial Na+ channel-targeted protease activity.Physiological reports · 2015Article
- Fast-response, sensitivitive and low-powered chemosensors by fusing nanostructured porous thin film and IDEs-microheater chip.Scientific reports · 2013Article
- A mathematical model for breath gas analysis of volatile organic compounds with special emphasis on acetone.Journal of mathematical biology · 2011Article
- Improved predictive models for plasma glucose estimation from multi-linear regression analysis of exhaled volatile organic compounds.Journal of applied physiology (Bethesda, Md. : 1985) · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The presence and the importance of acetone and its metabolism in diabetic ketoacidosis has largely been ignored. Therefore, we studied acetone metabolism in nine diabetic patients in moderate to severe ketoacidosis. The concentration of acetone in plasma, urine, and breath, and the rates of acetone production and elimination in breath and urine were determined and the rates of vivo metabolism were calculated. Plasma acetone concentrations (1.55-8.91 mM) were directly related and were generally greater than acetoacetate concentrations (1.16-6.08 mM). The rates of acetone production ranged from 68 to 581 mumol/min/1.73 m2, indicating the heterogeneous nature of the patients studied. The average acetone production rate was 265 mumol/min/1.73 m2 and accounted for about 52% of the estimated acetoacetate production rate. Urinary excretion of acetone remained constant and accounted for about 7% of the acetone production rate in all patients. There was a positive linear relationship between the percentage of the acetone production rate accounted for by excretion in breath and the plasma acetone concentration. At low plasma acetone concentrations, approximately 20%, and at high plasma acetone concentrations, approximately 80% of the production rate was accounted for by breath acetone. In contrast, there was a negative linear relationship between the percentage of acetone production rate undergoing in vivo metabolism and plasma acetone concentration. At low plasma acetone concentrations, approximately 75%, and at high concentrations, approximately 20% of acetone production rate was accounted for by in vivo metabolism. Radioactivity from 2-[14C]-acetone was variably present in plasma acetone, glucose, lipids and proteins. No radioactivity was found in plasma acetoacetate, beta-hydroxy butyrate or free fatty acids or other anionic compounds. Exchange rates of acetone into other metabolites could not be estimated because of non-steady-state precursor product relationships in these patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.