ArticleJournal of clinical pathology1982
Neutrophil granulocytic cell antigen defined by a monoclonal antibody--its distribution within normal haemic and non-haemic tissue.
Article in Journal of clinical pathology, 1982. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 53 citations in OpenAlex.
- Expression of CD15 in normal and metaplastic Paneth cells of the digestive tract.Journal of clinical pathology · 1996Article
- Binding of antibodies raised against tumour necrosis factor alpha (TNF alpha) to blood vessels and macrophages in inflamed synovial tissue.Rheumatology international · 1991Article
- Correlation of content of B cells and Leu7-positive cells with subtype and stage in lymphocyte predominance type Hodgkin's disease.Journal of cancer research and clinical oncology · 1988Article
- Spontaneous and induced immunoglobulin synthesis and anti-neutrophil cytoplasm antibodies in Wegener's granulomatosis: relation to leukocyte subpopulations in blood and active lesions.Rheumatology international · 1988Article
- Detailed phenotypic analysis of B-cell lymphoma using a panel of antibodies reactive in routinely fixed wax-embedded tissue.The American journal of pathology · 1987Article
- T-cell lymphomas of the stomach: morphological and immunological studies characterizing two cases of T-cell lymphoma.Virchows Archiv. A, Pathological anatomy and histopathology · 1987Article
- An evaluation of the utility of anti-granulocyte and anti-leukocyte monoclonal antibodies in the diagnosis of Hodgkin's disease.The American journal of pathology · 1986Article
- Presence of 3-fucosyl-N-acetyllactosamine shown by monoclonal antibody AGF 4.48 in Reed-Sternberg cells.Journal of clinical pathology · 1986Article
- Granulocyte and HLA-D region specific monoclonal antibodies in the diagnosis of Hodgkin's disease.Journal of clinical pathology · 1985Article
- Leu-M1--a marker for Reed-Sternberg cells in Hodgkin's disease. An immunoperoxidase study of paraffin-embedded tissues.The American journal of pathology · 1985Article
- Expression in normal adult, fetal, and neoplastic tissues of a carbohydrate differentiation antigen recognised by antigranulocyte mouse monoclonal antibodies.Journal of clinical pathology · 1985Article
- Article
- Nature of non-B, non-T lymphomas: an immunohistological study on frozen tissues using monoclonal antibodies.Journal of clinical pathology · 1984Article
- Characterization of two monoclonal antibodies obtained after immunization with human liver mitochondrial membrane preparations.The Biochemical journal · 1984Article
- Article
- Distribution of fucosylated N-acetyl lactosamine carbohydrate determinants during embryogenesis of the kidney in man.The Histochemical journalArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Monoclonal antibodies were raised against normal human bone marrow cells. One of the antibodies obtained, monoclonal antibody 3C4 (MA 3C4), the subject of this paper, was characterised by immunofluorescence studies with viable normal peripheral blood and bone marrow cells and by immunoperoxidase studies using paraffin sections. In bone marrow and peripheral blood MA 3C4 reacts selectively with cells of late neutrophilic granulopoiesis (myelocytes, metamyelocytes, and neutrophilic granulocytes). Cells of erythropoiesis, thrombopoiesis and lymphopoiesis are negative. In lymph node and spleen only neutrophils react with MA 3C4. In non-haemic tissue reactivity was seen with epithelial cells of a variety of different gland ducts. Thus the antigen detected by MA 3C4 can serve as a marker for neutrophil differentiation in normal haemopoiesis and as a marker for ductal epithelial cells of a variety of organs within non-haemic tissue. The antigen is formalin-resistant and can be detected in paraffin sections. The antibody thus appears to be a valuable reagent for both haematological research and for routine pathology.
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