ReviewDrugs1982
Tinidazole in anaerobic infections: a review of its antibacterial activity, pharmacological properties and therapeutic efficacy.
Review in Drugs, 1982. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 50 citations in OpenAlex.
- Comparative pharmacokinetics of metronidazole and tinidazole as influenced by administration route.Antimicrobial agents and chemotherapy · 1983Trial
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- Metal-free visible-light-promoted C(spGreen chemistry : an international journal and green chemistry resource : GC · 2021Article
- Nitroimidazoles for the treatment of TB: past, present and future.Future medicinal chemistry · 2011Review
- Pharmacokinetics and pharmacodynamics of the nitroimidazole antimicrobials.Clinical pharmacokinetics · 1999Review
- In vitro and in vivo activities of the nitroimidazole CGI 17341 against Mycobacterium tuberculosis.Antimicrobial agents and chemotherapy · 1993Article
- Clinical pharmacokinetics of metronidazole and other nitroimidazole anti-infectives.Clinical pharmacokinetics · 1992Review
- Penetration of tinidazole into skin blister fluid following its oral administration.European journal of clinical pharmacology · 1992Article
- Effect of different nitroheterocyclic compounds on aerobic, microaerophilic, and anaerobic bacteria.Antimicrobial agents and chemotherapy · 1986Article
- Concentrations of metronidazole and tinidazole in male genital tissues.Antimicrobial agents and chemotherapy · 1985Article
- Placental transfer of metronidazole and tinidazole in early human pregnancy after a single infusion.British journal of clinical pharmacology · 1984Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tinidazole, like the structurally-related drug metronidazole, was initially introduced for treating protozoal infections. However, both these nitroimidazole compounds are also active in vitro against most clinically important obligate anaerobes. Most of the clinical experience with tinidazole to date has involved prophylactic use to prevent postoperative anaerobic infection. Prospective placebo-controlled studies demonstrated that a single dose of tinidazole administered orally prior to elective colorectal surgery significantly reduced postoperative infection. Similarly, when given intravenously prior to appendectomy, tinidazole reduced the incidence of postoperative infection in some subgroups of patients. Although results of non-blinded studies with prophylactic tinidazole were encouraging when used in women undergoing gynaecological surgery (mainly hysterectomy), results from double-blind placebo-controlled studies in this situation have been somewhat equivocal. Thus, although the overall weight of evidence suggests that the drug is effective in this area of use, further study is needed to clarify its role in preventing anaerobic infection following gynaecological surgery compared with other antibiotics which can also be used for this purpose. Relatively few studies have been conducted with tinidazole in the treatment of established anaerobic infections, and this is an area needing further investigation. The drug is well tolerated when administered orally or intravenously.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.