ArticleThe Journal of experimental medicine1984
Clearance of circulating IgA immune complexes is mediated by a specific receptor on Kupffer cells in mice.
Article in The Journal of experimental medicine, 1984. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 87 citations in OpenAlex.
- Mesenchymal stem cells: a potential therapeutic strategy for IgA nephropathy.Frontiers in pharmacology · 2026Review
- Gut-liver axis in diabetes: Mechanisms and therapeutic opportunities.World journal of gastroenterology · 2025Review
- Causal relationships between immune cell phenotypes and primary glomerular diseases: genetic evidence from bidirectional Mendelian randomization study.Clinical kidney journal · 2025Article
- Autoimmune hepatitis in a patient with immunoglobulin A nephropathy: A case report.World journal of clinical cases · 2020Article
- IgA nephropathy: clearance kinetics of IgA-containing immune complexes.Seminars in immunopathology · 2018Review
- Acute glomerulonephritis with large confluent IgA-dominant deposits associated with liver cirrhosis.PloS one · 2018Article
- The kinetics of glomerular deposition of nephritogenic IgA.PloS one · 2014Article
- Association of liver cirrhosis related IgA nephropathy with portal hypertension.World journal of gastroenterology · 2007Article
- The N-glycans determine the differential blood clearance and hepatic uptake of human immunoglobulin (Ig)A1 and IgA2 isotypes.The Journal of experimental medicine · 2000Article
- Contribution of phagocytic cells and bacteria to the accumulation of technetium-99m labelled polyclonal human immunoglobulin at sites of inflammation.European journal of nuclear medicine · 1995Article
- Immunopathogenesis of experimental IgA nephropathy.Springer seminars in immunopathology · 1994Review
- Experimental IgA nephropathy: factors influencing IgA-immune complex deposition in the glomerulus.Springer seminars in immunopathology · 1994Review
- Mechanism of transfer of immune complexes from red blood cell CR1 to monocytes.Clinical and experimental immunology · 1992Article
- Kupffer cell depletion in vivo results in preferential elimination of IgG aggregates and immune complexes via specific Fc receptors on rat liver endothelial cells.Clinical and experimental immunology · 1991Article
- The polymeric immunoglobulin receptor (secretory component) mediates transport of immune complexes across epithelial cells: a local defense function for IgA.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Kupffer cell depletion in vivo results in clearance of large-sized IgA aggregates in rats by liver endothelial cells.Clinical and experimental immunology · 1991Article
- The structure and function of human IgA.The Biochemical journal · 1990Review
- Detection and characterization of circulating and glomerular immune complexes in experimental IgA nephropathy.Immunology · 1990Article
- Article
- Defective hepatic handling of IgA immune aggregates by mice with experimental IgA nephropathy.Immunology · 1989Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
To characterize the physiology of circulating IgA immune complexes (IgA-IC), the dynamics of IgA-IC removal by the liver were examined. After intravenous injection, covalently cross-linked IgA antibodies to the dinitrophenyl determinant were rapidly removed from the circulation by the liver. Immunofluorescence microscopy and light and electron microscope autoradiography showed that the IgA-IC were associated with Kupffer cells. With increasing doses of injected IgA-IC the clearance velocity approached a maximum, thus prolonging the circulation of IgA-IC. All these observations indicated a receptor-mediated process. Saturating doses of various potential receptor-blocking agents, heat-aggregated mouse IgG, microaggregated human serum albumin, and purified dimeric IgA did not influence the clearance pattern and hepatic uptake of radiolabeled IgA-IC. Mouse livers were also perfused via the portal vein with 1 microgram of IgA-IC. In the presence or absence of serum proteins, 43% of the perfused IgA-IC were removed in a single passage. This liver uptake was not reduced with simultaneous perfusion of large doses of aggregated mouse IgG, aggregated human serum albumin, or purified free dimeric mouse IgA. In contrast, the liver uptake of radiolabeled IgA-IC was decreased by 88% with the addition of 1 mg unlabeled IgA-IC. These observations support the conclusion that removal of IgA-IC from circulation is mediated by a specific IgA receptor on Kupffer cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.