ArticleThe Histochemical journal1984
Histochemical studies of the mechanism of the periodic acid-phenylhydrazine-Schiff (PAPS) procedure.
Article in The Histochemical journal, 1984. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- Histochemical classification based upon reaction types and its application to carbohydrate histochemistry.The Histochemical journal · 1990Review
- Sialic acid in colonic mucin: an evaluation of modified PAS reactions in single and combination histochemical procedures.The Histochemical journal · 1989Article
- Histochemical procedures for the simultaneous visualization of neutral sugars and either sialic acid and its side chain O-acyl variants or O-sulphate ester. I. Methods based upon the selective periodate oxidation of sialic acids.The Histochemical journal · 1987Article
- Histochemical procedures for the simultaneous visualization of neutral sugars and either sialic acid and its O-acyl variants or O-sulphate ester. II. Methods based upon the periodic acid-phenylhydrazine-Schiff reaction.The Histochemical journal · 1987Article
- Can 'mild' periodate oxidation be used for the specific histochemical identification of sialic acid residues?The Histochemical journal · 1986Article
- Histochemical staining of sulphated and non-sulphated sialomucin in intestinal epithelium: practical difficulties associated with the KOH-AB 1.0-PAPS method.The Histochemical journal · 1986Article
- Chemical and histochemical studies of normal and diseased human gastrointestinal tract. V. A differential diagnostic method for the histochemical classification of glycoproteins.The Histochemical journal · 1985Article
- Histochemical procedures for the simultaneous visualization of sialic acid, its side chain O-acyl variants and O-sulphate ester.The Histochemical journal · 1985Article
- Histochemical identification of side chain substituted O-acylated sialic acids: the PAT-KOH-Bh-PAS and the PAPT-KOH-Bh-PAS procedures.The Histochemical journal · 1984Article
- Methods for the identification of side chain O-acyl substituted sialic acids and for the simultaneous visualization of sialic acid, its side chain O-acyl variants and O-sulphate ester.The Histochemical journalArticle
- A new histochemical method for the selective periodate oxidation of total tissue sialic acids.The Histochemical journalArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Histochemical investigations of the periodic acid-phenylhydrazine-Schiff (PAPS) procedure were carried out on tissues containing carbohydrate macromolecules known to produce on periodate oxidation, only sialic acid monoaldehydes or hexosedialdehydes or mixtures of the two. The results indicated that the PAPS reaction is a generalized phenomenon independent of the hydrazine or hydrazide used, the nature of the Schiff reagent or the presence of anionic groups. It is proposed that phenylhydrazine condenses with periodate-engendered sialic acid monoaldehydes to yield the corresponding phenylhydrazone and with periodate-engendered dialdehydes to yield the corresponding morpholine or azido derivatives. Subsequent Schiff treatment results in the reversal of the blockade of sialic acid monoaldehydes but not of the dialdehydes, thus leading to selective Schiff staining of sialic acid residues.
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