ArticleAntimicrobial agents and chemotherapy1984
Antileishmanial activity of chlorpromazine.
Article in Antimicrobial agents and chemotherapy, 1984. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 64 citations in OpenAlex.
- Repurposing as a strategy for the discovery of new anti-leishmanials: the-state-of-the-art.Parasitology · 2018Review
- New Approaches to Overcome Transport Related Drug Resistance in Trypanosomatid Parasites.Frontiers in pharmacology · 2016Review
- Clinically Available Medicines Demonstrating Anti-Toxoplasma Activity.Antimicrobial agents and chemotherapy · 2015Review
- In Vitro and In Vivo Antileishmanial Effects of Pistacia khinjuk against Leishmania tropica and Leishmania major.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Regulatory volume decrease in Leishmania mexicana: effect of anti-microtubule drugs.Memorias do Instituto Oswaldo Cruz · 2013Article
- Novel anti-Cryptosporidium activity of known drugs identified by high-throughput screening against parasite fatty acyl-CoA binding protein (ACBP).The Journal of antimicrobial chemotherapy · 2012Article
- In vivo efficacy of gum obtained pistacia atlantica in experimental treatment of cutaneous leishmaniasis.Iranian journal of public health · 2010Article
- Thioridazine: resurrection as an antimicrobial agent?British journal of clinical pharmacology · 2007Review
- Effect of mitonafide analogs on topoisomerase II of Leishmania chagasi.Antimicrobial agents and chemotherapy · 1996Article
- The use of a water-soluble formazan complex to quantitate the cell number and mitochondrial function of Leishmania major promastigotes.Parasitology research · 1994Article
- Licochalcone A, a novel antiparasitic agent with potent activity against human pathogenic protozoan species of Leishmania.Antimicrobial agents and chemotherapy · 1993Article
- Cytotoxicity of acridine compounds for Leishmania promastigotes in vitro.Antimicrobial agents and chemotherapy · 1992Article
- Effect of immunoglobulin M from normal human serum on Leishmania donovani promastigote agglutination, complement-mediated killing, and phagocytosis by human monocytes.Infection and immunity · 1989Article
- Effect of calmodulin inhibitors on viability and mitochondrial potential of Plasmodium falciparum in culture.Antimicrobial agents and chemotherapy · 1986Article
- Efficacy of the Bunium persicum (Boiss) Essential Oil against Acute Toxoplasmosis in Mice Model.Iranian journal of parasitologyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The antiprotozoal activity of chlorpromazine against the pathogenic protozoan Leishmania donovani, in both its amastigote and promastigote stages, was characterized. Chlorpromazine at concentrations greater than or equal to 3.12 micrograms/ml (9.8 X 10(-6) M) produced a significant reduction in viable promastigotes. The minimal protozoacidal concentration for promastigotes, defined as that concentration which produced greater than or equal to 90% reduction in viable parasites after 18 h, was 13.8 micrograms/ml. The results were similar when promastigote viability was assessed by flagellar motility or by the ability of drug-exposed or control promastigotes to incorporate [3H]uridine and [3H]leucine. Exposure of promastigotes to 50 micrograms of chlorpromazine per ml reduced O2 consumption by 87% within 30 min and immobilized 97% of parasites. Morphological disruption of promastigotes was observed by electron microscopy. The mean minimal protozoacidal concentration of chlorpromazine for amastigotes was 13.2 micrograms/ml. Chlorpromazine given orally (20 mg/kg per day for 14 days) reduced the parasite burden in L. donovani-infected hamsters by 64.2% (P less than 0.01) as measured by the number of amastigotes in touch preparations of livers and by 67.9% (P = 0.03) as measured by the number of promastigotes derived from homogenates of spleens. This dose is ca. 10-fold greater than that tolerated by patients being treated for psychiatric illness. Although chlorpromazine will probably not be useful in the treatment of human visceral leishmaniasis, the data suggest that less-toxic phenothiazines might prove to be effective.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.