ArticleThe Journal of cell biology1984
A localized surface protein of guinea pig sperm exhibits free diffusion in its domain.
Article in The Journal of cell biology, 1984. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 89 citations in OpenAlex.
- Assessment of the frequency of sperm annulus defects in a large cohort of patients presenting asthenozoospermia.Basic and clinical andrology · 2015Article
- Functional and Evolutionary Analysis of the CASPARIAN STRIP MEMBRANE DOMAIN PROTEIN Family.Plant physiology · 2014Article
- Article
- Transport and localization of signaling proteins in ciliated cells.Vision research · 2012Review
- The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization.EMBO reports · 2012Review
- Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility.Molecular reproduction and development · 2012Review
- The annulus of the mouse sperm tail is required to establish a membrane diffusion barrier that is engaged during the late steps of spermiogenesis.Biology of reproduction · 2010Article
- Mechanisms underlying the micron-scale segregation of sterols and GM1 in live mammalian sperm.Journal of cellular physiology · 2009Article
- Cyclic 3',5'-AMP causes ADAM1/ADAM2 to rapidly diffuse within the plasma membrane of guinea pig sperm.Biology of reproduction · 2008Article
- Barriers to diffusion of plasma membrane proteins form early during guinea pig spermiogenesis.Biophysical journal · 1997Article
- Breaching the diffusion barrier that compartmentalizes the transmembrane glycoprotein CE9 to the posterior-tail plasma membrane domain of the rat spermatozoon.The Journal of cell biology · 1993Article
- Endoproteolytic cleavage in the extracellular domain of the integral plasma membrane protein CE9 precedes its redistribution from the posterior to the anterior tail of the rat spermatozoon during epididymal maturation.The Journal of cell biology · 1991Article
- Morphology of mammalian sperm membranes during differentiation, maturation, and capacitation.Journal of electron microscopy technique · 1990Review
- Boar sperm membranes antigens. I. Topography of a mobile glycoprotein of the sperm cell membrane.Histochemistry · 1990Article
- Distribution and lateral mobility of voltage-dependent sodium channels in neurons.The Journal of cell biology · 1988Article
- High lateral mobility of endogenous and transfected alkaline phosphatase: a phosphatidylinositol-anchored membrane protein.The Journal of cell biology · 1987Article
- Redistribution of mouse sperm surface galactosyltransferase after the acrosome reaction.The Journal of cell biology · 1987Article
- Lateral diffusion of the PH-20 protein on guinea pig sperm: evidence that barriers to diffusion maintain plasma membrane domains in mammalian sperm.The Journal of cell biology · 1987Article
- The Thy-1 antigen exhibits rapid lateral diffusion in the plasma membrane of rodent lymphoid cells and fibroblasts.Proceedings of the National Academy of Sciences of the United States of America · 1987Article
- Identification and purification of a sperm surface protein with a potential role in sperm-egg membrane fusion.The Journal of cell biology · 1987Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Using the technique of fluorescence redistribution after photobleaching, we are studying the cellular mechanisms involved in localizing surface molecules to particular domains. A number of antigens localized to discrete surface regions have been identified with monoclonal antibodies on guinea pig sperm cells ( Primakoff , P., and D. G. Myles , 1983, Dev. Biol., 98:417-428). One of these monoclonal antibodies, PT-1, binds exclusively to the posterior tail region of the sperm cell surface. PT-1 recognizes an integral membrane protein that in complex with n-octyl-beta-D-glucopyranoside has a sedimentation coefficient of 6.8S in sucrose density gradients. Fluorescence redistribution after photobleaching measurements reveal that within its surface domain the PT-1 antigen diffuses rapidly (D = 2.5 X 10(-9) cm2/s) and completely (greater than 90% recovery after bleaching). These results rule out for this membrane protein all models that invoke immobilization as a mechanism for maintaining localization. We propose that the mechanism for localization of the PT-1 antigen may be a barrier to diffusion at the domain boundary.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.