ArticleGut1984
Oxalate and chloride absorption by the rabbit colon: sensitivity to metabolic and anion transport inhibitors.
Article in Gut, 1984. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- The anion exchanger PAT-1 (Slc26a6) does not participate in oxalate or chloride transport by mouse large intestine.Pflugers Archiv : European journal of physiology · 2021Article
- Physiological and Pathological Functions of SLC26A6.Frontiers in medicine · 2020Review
- Absence of the sulfate transporter SAT-1 has no impact on oxalate handling by mouse intestine and does not cause hyperoxaluria or hyperoxalemia.American journal of physiology. Gastrointestinal and liver physiology · 2019Article
- The role of intestinal oxalate transport in hyperoxaluria and the formation of kidney stones in animals and man.Urolithiasis · 2017Review
- Oxalate, inflammasome, and progression of kidney disease.Current opinion in nephrology and hypertension · 2016Review
- Intestinal adaptations in chronic kidney disease and the influence of gastric bypass surgery.Experimental physiology · 2014Review
- Transcellular oxalate and Cl- absorption in mouse intestine is mediated by the DRA anion exchanger Slc26a3, and DRA deletion decreases urinary oxalate.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- Net intestinal transport of oxalate reflects passive absorption and SLC26A6-mediated secretion.Journal of the American Society of Nephrology : JASN · 2011Article
- The roles and mechanisms of intestinal oxalate transport in oxalate homeostasis.Seminars in nephrology · 2008Review
- Intestinal transport of an obdurate anion: oxalate.Urological research · 2005Review
- Angiotensin II involvement in adaptive enteric oxalate excretion in rats with chronic renal failure induced by hyperoxaluria.Urological research · 2003Article
- Oxalate binding proteins in calcium oxalate nephrolithiasis.Urological research · 2003Review
- Occurrence of histone-related oxalate binding in rat liver nucleus.Molecular and cellular biochemistry · 1996Article
- Mechanisms of oxalate absorption and secretion across the rabbit distal colon.Pflugers Archiv : European journal of physiology · 1994Article
- Characteristics of the transport of oxalate and other ions across rabbit proximal colon.Pflugers Archiv : European journal of physiology · 1993Article
- Review
- Oxalate transport in cultured porcine renal epithelial cells.Urological research · 1992Article
- Treatment of enteric hyperoxaluria.Postgraduate medical journal · 1991Review
- Effects of acid-base variables on ion transport in rat colon.The Journal of clinical investigation · 1988Article
- Oxalate transport by anion exchange across rabbit ileal brush border.The Journal of clinical investigation · 1986Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The effects of transport inhibitors on the movements of oxalate and chloride across the isolated short circuited rabbit colon were studied. Net oxalate absorption was shown in this species and was shown to be an energy dependent process as indicated by its sensitivity to 2-4 dinitrophenol (DNP) 10(-4)M. Mucosal addition of 4-acetamido-4-isothiocyano-2,-stilbene-2,2'-disulfonic acid (SITS) 10(-4)M abolished the net flux of both oxalate and chloride. Acetazolamide (8 mM) in bicarbonate free buffer significantly reduced the mucosal to serosal flux of both anions. These results suggest that in rabbit colon, oxalate and chloride share a common transport pathway and implicate the chloride bicarbonate exchange system. This study also confirms that chloride absorption by the short circuited rabbit colon is an electrically silent process and presents evidence that suggests that chloride absorption is mediated by a chloride bicarbonate exchange system located in the apical membrane of absorbing colonic epithelial cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.